Expression of mPGES1 and p16 in feline and human oral squamous cell carcinoma: A comparative oncology approach

• Published in: Veterinary & comparative oncology 2024-06, Vol.22 (2), p.204-216
• Main Authors: Nasry, Walaa Hamed Shaker, Jones, Kathleen, Rodriguez‐Lecompte, Juan Carlos, Tesch, Marvin, Martin, Chelsea K.
• Format: Article
• Language: English
• Subjects: Animals; Carcinoma, Squamous Cell - metabolism; Carcinoma, Squamous Cell - pathology; Carcinoma, Squamous Cell - veterinary; Cat Diseases - metabolism; Cat Diseases - pathology; Cats; CD147; comparative oncology; COX‐2; Cyclin-Dependent Kinase Inhibitor p16 - metabolism; Female; Gene Expression Regulation, Neoplastic; Humans; Male; Mouth Neoplasms - metabolism; Mouth Neoplasms - pathology; Mouth Neoplasms - veterinary; mPGES1; oral squamous cell carcinoma; p16; Prostaglandin-E Synthases - genetics; Prostaglandin-E Synthases - metabolism
• ISSN: 1476-5810; 1476-5829
• DOI: 10.1111/vco.12967

Comparative cancer studies help us determine if discoveries in one species apply to another. Feline and human oral squamous cell carcinoma (FOSCC and HOSCC) are invasive tumours in which inflammation and abnormal p16 expression are reported. Immunohistochemistry was used to determine the expression of p16 and microsomal prostaglandin E2 synthase 1 (mPGES1) in 42 HOSCC and 45 FOSCC samples with known expression of cyclooxygenase 2 (COX2) and cluster of differentiation 147 (CD147). High p16 expression was more common in HOSCC tumour cells compared to adjacent stroma and oral epithelium (p  0.05) differences in marker expression between high and low mPGES1 expressing tumours in both species, including high p16 observed more commonly in high mPGES1 tumours, and COX‐2 positive tumours being more common in low mPGES1 tumours. High CD147 HOSCC tumours were more common in the high mPGES1 HOSCC group (p