Changes in antibody titer after four and five doses of the SARS‐CoV‐2 vaccine in Japanese post‐kidney transplant patients

Introduction Immunosuppressed patients exhibit low antibody acquisition rates following severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) vaccination. Kidney transplant recipients previously exhibited low antibody acquisition rates after two vaccine doses, which increased after the third...

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Published in:Therapeutic apheresis and dialysis 2024-08, Vol.28 (4), p.489-498
Main Authors: Fujieda, Kumiko, Tanaka, Akihito, Kikuchi, Ryosuke, Takai, Nami, Saito, Shoji, Yasuda, Yoshinari, Sano, Yuta, Kato, Masashi, Furuhashi, Kazuhiro, Maruyama, Shoichi
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Language:English
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antibody acquisition rate
COVID‐19
immunocompromised
kidney transplantation
SARS‐CoV‐2
vaccination
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container_title Therapeutic apheresis and dialysis
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creator Fujieda, Kumiko
Tanaka, Akihito
Kikuchi, Ryosuke
Takai, Nami
Saito, Shoji
Yasuda, Yoshinari
Sano, Yuta
Kato, Masashi
Furuhashi, Kazuhiro
Maruyama, Shoichi
description Introduction Immunosuppressed patients exhibit low antibody acquisition rates following severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) vaccination. Kidney transplant recipients previously exhibited low antibody acquisition rates after two vaccine doses, which increased after the third dose. We evaluated antibody titers of Japanese post‐kidney transplant patients after the fourth and fifth vaccinations. Methods Antibody titers for SARS‐CoV‐2 spike protein were measured between 3 weeks and 3 months after the fourth or fifth vaccination. Results Increased antibody acquisition rates were observed after the fourth (75.0% antibody‐positive) and fifth (81.5% antibody‐positive) vaccinations. The antibody‐acquired group after the fourth vaccination exhibited a higher body mass index and estimated glomerular filtration rate (eGFR) than the non‐acquired group. A higher eGFR was associated with antibody acquisition after the fifth vaccination. Conclusion In Japanese post‐kidney transplant patients, the antibody acquisition rate increased with each vaccine additional dose. Additional vaccinations are recommended to protect against SARS‐CoV‐2 infection.
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Kidney transplant recipients previously exhibited low antibody acquisition rates after two vaccine doses, which increased after the third dose. We evaluated antibody titers of Japanese post‐kidney transplant patients after the fourth and fifth vaccinations. Methods Antibody titers for SARS‐CoV‐2 spike protein were measured between 3 weeks and 3 months after the fourth or fifth vaccination. Results Increased antibody acquisition rates were observed after the fourth (75.0% antibody‐positive) and fifth (81.5% antibody‐positive) vaccinations. The antibody‐acquired group after the fourth vaccination exhibited a higher body mass index and estimated glomerular filtration rate (eGFR) than the non‐acquired group. A higher eGFR was associated with antibody acquisition after the fifth vaccination. Conclusion In Japanese post‐kidney transplant patients, the antibody acquisition rate increased with each vaccine additional dose. Additional vaccinations are recommended to protect against SARS‐CoV‐2 infection.</description><identifier>ISSN: 1744-9979</identifier><identifier>ISSN: 1744-9987</identifier><identifier>EISSN: 1744-9987</identifier><identifier>DOI: 10.1111/1744-9987.14114</identifier><identifier>PMID: 38385762</identifier><language>eng</language><publisher>Kyoto, Japan: John Wiley &amp; Sons Australia, Ltd</publisher><subject>antibody acquisition rate ; COVID‐19 ; immunocompromised ; kidney transplantation ; SARS‐CoV‐2 ; vaccination</subject><ispartof>Therapeutic apheresis and dialysis, 2024-08, Vol.28 (4), p.489-498</ispartof><rights>2024 International Society for Apheresis and Japanese Society for Apheresis.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2974-e86820c9584f8a59206e5ddf2c41a1f7793a5acc98b7aff9d46f9ff10a872d3e3</cites><orcidid>0000-0003-2476-688X ; 0000-0003-2086-9507</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38385762$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fujieda, Kumiko</creatorcontrib><creatorcontrib>Tanaka, Akihito</creatorcontrib><creatorcontrib>Kikuchi, Ryosuke</creatorcontrib><creatorcontrib>Takai, Nami</creatorcontrib><creatorcontrib>Saito, Shoji</creatorcontrib><creatorcontrib>Yasuda, Yoshinari</creatorcontrib><creatorcontrib>Sano, Yuta</creatorcontrib><creatorcontrib>Kato, Masashi</creatorcontrib><creatorcontrib>Furuhashi, Kazuhiro</creatorcontrib><creatorcontrib>Maruyama, Shoichi</creatorcontrib><title>Changes in antibody titer after four and five doses of the SARS‐CoV‐2 vaccine in Japanese post‐kidney transplant patients</title><title>Therapeutic apheresis and dialysis</title><addtitle>Ther Apher Dial</addtitle><description>Introduction Immunosuppressed patients exhibit low antibody acquisition rates following severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) vaccination. Kidney transplant recipients previously exhibited low antibody acquisition rates after two vaccine doses, which increased after the third dose. We evaluated antibody titers of Japanese post‐kidney transplant patients after the fourth and fifth vaccinations. Methods Antibody titers for SARS‐CoV‐2 spike protein were measured between 3 weeks and 3 months after the fourth or fifth vaccination. Results Increased antibody acquisition rates were observed after the fourth (75.0% antibody‐positive) and fifth (81.5% antibody‐positive) vaccinations. The antibody‐acquired group after the fourth vaccination exhibited a higher body mass index and estimated glomerular filtration rate (eGFR) than the non‐acquired group. A higher eGFR was associated with antibody acquisition after the fifth vaccination. Conclusion In Japanese post‐kidney transplant patients, the antibody acquisition rate increased with each vaccine additional dose. Additional vaccinations are recommended to protect against SARS‐CoV‐2 infection.</description><subject>antibody acquisition rate</subject><subject>COVID‐19</subject><subject>immunocompromised</subject><subject>kidney transplantation</subject><subject>SARS‐CoV‐2</subject><subject>vaccination</subject><issn>1744-9979</issn><issn>1744-9987</issn><issn>1744-9987</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNqFkMtOAyEUhonReF-7MyzdtA4MM8CyabzGRONtS-hwULSFcZjWdKWP4DP6JDK2diuLwwl8fIf8CB2QrE_SOiacsZ6UgvcJI4Stoe3Vyfqq53IL7cT4kmWUsjzfRFu5yEXBS7qNPobP2j9BxM5j7Vs3CmaOW9dCg7Xtqg3T1HqDrZsBNiEmNljcPgO-G9zefX9-DcNjqhTPdFU5D53pUtfaQwRch9imy1dnPCRvo32sx2kOrnXrwLdxD21YPY6wv9x30cPpyf3wvHd1fXYxHFz1Kio564EoBc0qWQhmhS4kzUoojLG0YkQTy7nMdZHmSzHi2lppWGmltSTTglOTQ76LjhbeuglvU4itmrhYwTh9BsI0KirzjHFaMpHQ4wVaNSHGBqyqGzfRzVyRTHWpqy5X1WWsflNPLw6X8uloAmbF_8WcgGIBvLsxzP_zqfvBzUL8A9s0kDE</recordid><startdate>202408</startdate><enddate>202408</enddate><creator>Fujieda, Kumiko</creator><creator>Tanaka, Akihito</creator><creator>Kikuchi, Ryosuke</creator><creator>Takai, Nami</creator><creator>Saito, Shoji</creator><creator>Yasuda, Yoshinari</creator><creator>Sano, Yuta</creator><creator>Kato, Masashi</creator><creator>Furuhashi, Kazuhiro</creator><creator>Maruyama, Shoichi</creator><general>John Wiley &amp; Sons Australia, Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2476-688X</orcidid><orcidid>https://orcid.org/0000-0003-2086-9507</orcidid></search><sort><creationdate>202408</creationdate><title>Changes in antibody titer after four and five doses of the SARS‐CoV‐2 vaccine in Japanese post‐kidney transplant patients</title><author>Fujieda, Kumiko ; Tanaka, Akihito ; Kikuchi, Ryosuke ; Takai, Nami ; Saito, Shoji ; Yasuda, Yoshinari ; Sano, Yuta ; Kato, Masashi ; Furuhashi, Kazuhiro ; Maruyama, Shoichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2974-e86820c9584f8a59206e5ddf2c41a1f7793a5acc98b7aff9d46f9ff10a872d3e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>antibody acquisition rate</topic><topic>COVID‐19</topic><topic>immunocompromised</topic><topic>kidney transplantation</topic><topic>SARS‐CoV‐2</topic><topic>vaccination</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fujieda, Kumiko</creatorcontrib><creatorcontrib>Tanaka, Akihito</creatorcontrib><creatorcontrib>Kikuchi, Ryosuke</creatorcontrib><creatorcontrib>Takai, Nami</creatorcontrib><creatorcontrib>Saito, Shoji</creatorcontrib><creatorcontrib>Yasuda, Yoshinari</creatorcontrib><creatorcontrib>Sano, Yuta</creatorcontrib><creatorcontrib>Kato, Masashi</creatorcontrib><creatorcontrib>Furuhashi, Kazuhiro</creatorcontrib><creatorcontrib>Maruyama, Shoichi</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Therapeutic apheresis and dialysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fujieda, Kumiko</au><au>Tanaka, Akihito</au><au>Kikuchi, Ryosuke</au><au>Takai, Nami</au><au>Saito, Shoji</au><au>Yasuda, Yoshinari</au><au>Sano, Yuta</au><au>Kato, Masashi</au><au>Furuhashi, Kazuhiro</au><au>Maruyama, Shoichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in antibody titer after four and five doses of the SARS‐CoV‐2 vaccine in Japanese post‐kidney transplant patients</atitle><jtitle>Therapeutic apheresis and dialysis</jtitle><addtitle>Ther Apher Dial</addtitle><date>2024-08</date><risdate>2024</risdate><volume>28</volume><issue>4</issue><spage>489</spage><epage>498</epage><pages>489-498</pages><issn>1744-9979</issn><issn>1744-9987</issn><eissn>1744-9987</eissn><abstract>Introduction Immunosuppressed patients exhibit low antibody acquisition rates following severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) vaccination. Kidney transplant recipients previously exhibited low antibody acquisition rates after two vaccine doses, which increased after the third dose. We evaluated antibody titers of Japanese post‐kidney transplant patients after the fourth and fifth vaccinations. Methods Antibody titers for SARS‐CoV‐2 spike protein were measured between 3 weeks and 3 months after the fourth or fifth vaccination. Results Increased antibody acquisition rates were observed after the fourth (75.0% antibody‐positive) and fifth (81.5% antibody‐positive) vaccinations. The antibody‐acquired group after the fourth vaccination exhibited a higher body mass index and estimated glomerular filtration rate (eGFR) than the non‐acquired group. A higher eGFR was associated with antibody acquisition after the fifth vaccination. Conclusion In Japanese post‐kidney transplant patients, the antibody acquisition rate increased with each vaccine additional dose. 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subjects antibody acquisition rate
COVID‐19
immunocompromised
kidney transplantation
SARS‐CoV‐2
vaccination
title Changes in antibody titer after four and five doses of the SARS‐CoV‐2 vaccine in Japanese post‐kidney transplant patients
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