Fabrication and characterization of a Bi2O3-modified chitosan@ZIF-8 nanocomposite for enhanced drug loading-releasing efficacy

In this study, a simple novel hybrid mesoporous nanomaterial derived from a metal-organic framework (ZIF-8) and chitosan, which were coated on green bismuth oxide, has been successfully synthesized, characterized, and applied to investigate its dapsone loading-releasing capability in the aqueous med...

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Bibliographic Details
Published in:International journal of biological macromolecules 2024-04, Vol.263, p.130295-130295, Article 130295
Main Authors: Khalili, Zahra, Motakef Kazemi, Negar, Jafari Azar, Zahra, Mosavi, Zahra, Hasanzadeh, Mahdi
Format: Article
Language:English
Subjects:
Bismuth oxide
Chitosan
coordination polymers
dapsone
Drug delivery
Fourier transform infrared spectroscopy
Green synthesis
hydrogen
Mentha
mesosphere
nanocomposites
nanomaterials
phosphates
porous media
thermogravimetry
transmission electron microscopy
X-ray diffraction
ZIF-8
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Summary:In this study, a simple novel hybrid mesoporous nanomaterial derived from a metal-organic framework (ZIF-8) and chitosan, which were coated on green bismuth oxide, has been successfully synthesized, characterized, and applied to investigate its dapsone loading-releasing capability in the aqueous media. This suggested nanocomposite showed promise for drug loading from water b using hydrogen bonds, pi-pi, and electrostatic interactions. Structural and morphological analyses were performed on the proposed green synthesized nanocomposite through scanning electron microscopy, X-ray diffraction, Fourier transform infrared spectroscopy, transmission electron microscopy, Brunauer–Emmett–Teller analysis, and thermogravimetric analysis. Various influencing parameters, including pH, nanocomposite dose, and contact time, were investigated to optimize the dapsone loading process. Utilizing the non-linear optimization methodology, the results show that dapsone-loading efficiency was >85 % for 50 mg.L−1 of dapsone drug. The optimum parameters for achieving maximal loading of dapsone drug were pH = 6.8, hybrid mesosphere dose = 2.6 mg.mL−1, and time = 53 min. Based on the release investigations, the dapsone-loaded nanocomposite was put into phosphate buffer saline, at pH = 7.4 and T = 37 °C, with a maximum efficiency of 93.9 after 24 h.
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2024.130295