Novel reference range values for serum testosterone: a cross-sectional study of 200,000 males

Purpose To better understand the effects of aging, metabolic syndrome, diurnal variation, and seasonal variation on serum testosterone levels in the context of current guideline statements on testosterone deficiency. Methods This cross-sectional study utilized the United Kingdom Biobank. Physical ex...

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Bibliographic Details
Published in:Journal of endocrinological investigation 2024, Vol.47 (9), p.2261-2268
Main Authors: Fantus, Richard J., Greenberg, Daniel R., Chang, Cecilia, Helfand, Brian T., Xu, Jianfeng, Wei, Jun, Shoag, Jonathan E., Nangia, Ajay K., Brannigan, Robert E., Halpern, Joshua A.
Format: Article
Language:English
Subjects:
Aging
Blood levels
Cross-sectional studies
Diurnal variations
Endocrinology
Hypogonadism
Internal Medicine
Medicine
Medicine & Public Health
Metabolic Diseases
Metabolic syndrome
Original Article
Population studies
Seasonal variations
Testosterone
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Summary:Purpose To better understand the effects of aging, metabolic syndrome, diurnal variation, and seasonal variation on serum testosterone levels in the context of current guideline statements on testosterone deficiency. Methods This cross-sectional study utilized the United Kingdom Biobank. Physical examination, anthropomorphic measurements, and laboratory evaluation were performed at the time of enrollment from 2006 to 2010. The primary outcomes were the effect of age, the presence of metabolic syndrome, the time of day, and the month of the year on serum testosterone levels. Results Among 197,883 included men, the 5th, 25th, 50th, 75th and 95th percentile testosterone levels in men without metabolic syndrome were significantly higher than those in men with metabolic syndrome at every decade of life (p 
ISSN:1720-8386
0391-4097
1720-8386
DOI:10.1007/s40618-024-02319-0