Systematic review and meta-analysis of diagnostic test accuracy of ST-segment elevation for acute coronary occlusion

• Published in: International journal of cardiology 2024-05, Vol.402, p.131889, Article 131889
• Main Authors: de Alencar Neto, José Nunes, Scheffer, Matheus Kiszka, Correia, Bruno Pinotti, Franchini, Kleber Gomes, Felicioni, Sandro Pinelli, De Marchi, Mariana Fuziy Nogueira
• Format: Article
• Language: English
• Subjects: Coronary occlusion; Electrocardiography; Myocardial infarction; Sensitivity; Specificity
• ISSN: 0167-5273; 1874-1754; 1874-1754
• DOI: 10.1016/j.ijcard.2024.131889

To evaluate the diagnostic sensitivity and specificity of ST-segment elevation on a 12‑lead ECG in detecting ACO across any coronary artery, challenging the current STEMI-NSTEMI paradigm. Studies from MEDLINE and Scopus (2012−2023) comparing ECG findings with coronary angiograms were systematically reviewed and analyzed following PRISMA-DTA guidelines. QUADAS-2 assessed the risk of bias. Studies included focused on AMI patients and provided data enabling the construction of contingency tables for sensitivity and specificity calculation, excluding those with non-ACS conditions, outdated STEMI criteria, or a specific focus on bundle branch blocks or other complex diagnoses. Data were extracted systematically and pooled test accuracy estimates were computed using MetaDTA software, employing bivariate analyses for within- and between-study variation. The primary outcomes measured were the sensitivity and specificity of ST-segment elevation in detecting ACO. Three studies with 23,704 participants were included. The pooled sensitivity of ST-segment elevation for detecting ACO was 43.6% (95% CI: 34.7%–52.9%), indicating that over half of ACO cases may not exhibit ST-segment elevation. The specificity was 96.5% (95% CI: 91.2%–98.7%). Additional analysis using the OMI-NOMI strategy showed improved sensitivity (78.1%, 95% CI: 62.7%–88.3%) while maintaining similar specificity (94.4%, 95% CI: 88.6%–97.3%). The findings reveal a significant diagnostic gap in the current STEMI-NSTEMI paradigm, with over half of ACO cases potentially lacking ST-segment elevation. The OMI-NOMI strategy could offer an improved diagnostic approach. The high heterogeneity and limited number of studies necessitate cautious interpretation and further research in diverse settings. •Current ST elevation criteria misses many acute coronary occlusions.•Urges updating myocardial infarction diagnostic methods.•Meta-analysis questions current ECG criteria.•Study suggests wider scope for ACO detection.•Research may shift cardiology clinical guidelines.