Global prevalence of poor sleep quality in cancer patients: A systematic review and meta-analysis

• Published in: General hospital psychiatry 2024-03, Vol.87, p.92-102
• Main Authors: Chen, Meng-Yi, Zheng, Wan-Ying, Liu, Yu-Fei, Li, Xiao-Hong, Lam, Mei Ieng, Su, Zhaohui, Cheung, Teris, Ungvari, Gabor S., Tang, Lili, Ng, Chee H., Zhang, Qinge, Xiang, Yu-Tao
• Format: Article
• Language: English
• Subjects: Cancer; Global Health - statistics & numerical data; Humans; Meta-analysis; Neoplasms - epidemiology; Prevalence; Sleep quality; Sleep Wake Disorders - epidemiology
• ISSN: 0163-8343; 1873-7714; 1873-7714
• DOI: 10.1016/j.genhosppsych.2023.12.004

Poor sleep quality is common in patients with cancer, but the prevalence rates varied widely across studies. This systematic review and meta-analysis examined the pooled prevalence of poor sleep quality among patients with cancer. Systematic literature searches were independently conducted in the major databases (Web of Science, PubMed, EMBASE and PsycINFO). Studies that reported the prevalence of poor sleep quality in patients with cancer were analyzed using a random effects model. Funnel plots and Egger's tests were used to assess publication bias. Statistical analyses were performed using R software. A total of 59 epidemiological studies involving 16,223 patients were included. The pooled prevalence of poor sleep quality in patients with cancer was 57.4% [95% confidence interval (CI): 53.3% - 61.6%]. Additionally, three comparative studies with 372 patients and 412 healthy controls were included. Compared to healthy controls, patients with cancer had a significantly higher risk for poor sleep quality [odd ratio (OR) = 3.0; 95%CI: 1.2–7.2; P