Identification of Lydicamycins as Main Antioomycete Compounds from the Biocontrol Agent Streptomyces sp. NEAU-S7GS2

• Published in: Journal of agricultural and food chemistry 2024-03, Vol.72 (9), p.4649-4657
• Main Authors: Xie, Yimeng, Du, Shihua, Su, Ziwei, Wang, Han, Qi, Huan, Wang, Jidong, Wang, Xiangjing, Xiang, Wensheng, Zhang, Hui, Zhang, Ji
• Format: Article
• Language: English
• Subjects: Agricultural and Environmental Chemistry; Crops, Agricultural; Fatty Alcohols; Glycine max; Phytophthora; Plant Diseases - microbiology; Plant Diseases - prevention & control; Pyrrolidinones; Pythium; Streptomyces
• ISSN: 0021-8561; 1520-5118
• DOI: 10.1021/acs.jafc.3c08149

Oomycetes are well-known phytopathogens that seriously threaten many important crops worldwide. In this study, the endophytic actinobacterium Streptomyces sp. NEAU-S7GS2 demonstrated significant antagonistic activity against Phytophthora and Pythium and showed a potent biocontrol effect on suppression of soybean phytophthora root rot and pepper phytophthora blight. Two compounds were subsequently isolated as the main active components by bioassay-guided fractionation and identified as lydicamycins A and B. These two compounds showed high antioomycete activity against Phytophthora and Pythium with EC50 values of 0.73–2.67 μg/mL, which are equal to or lower than those of commercialized drug metalaxyl. In vivo bioassay using detached leaves demonstrated that lydicamycin A had a better control efficiency against soybean phytophthora root rot than metalaxyl. Taken together, these results suggest that the biocontrol agent Streptomyces sp. NEAU-S7GS2 and lydicamycins have the potential to be developed as promising pesticides to control diseases caused by oomycetes.