Isolated Cutaneous Granuloma Caused by Candida Parapsilosis: Case Report and Literature Review

Candidal granuloma is an uncommon type of deep chronic cutaneous candidiasis. Candida albican is the most common causative pathogen for candidal granuloma. We report herein the original case of a 69-year-old Chinese woman presented with a 3-year of painful cutaneous lesion on the back of left hand....

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Bibliographic Details
Published in:Mycopathologia (1975) 2024-04, Vol.189 (2), p.20-20, Article 20
Main Authors: Yang, Xinyu, Jin, Xingji, Yang, Zhusheng, Wang, Youxue, Wei, Aihua, Yang, Xiumin
Format: Article
Language:English
Subjects:
Aged
Biomedical and Life Sciences
Biopsy
Candida
Candida parapsilosis
Candidiasis
Candidiasis - diagnosis
Candidiasis - drug therapy
Candidiasis, Chronic Mucocutaneous
Case Report
Cellulitis
Dermis
Eukaryotic Microbiology
Female
Granuloma
Granuloma - diagnosis
Granuloma - drug therapy
Granulomas
Horizontal cells
Humans
Hyphae
Immunocompromised hosts
Itraconazole
Life Sciences
Literature reviews
Medical Microbiology
Microbial Ecology
Microbiology
Pathogens
Plant Sciences
Terbinafine
Ulcers
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Summary:Candidal granuloma is an uncommon type of deep chronic cutaneous candidiasis. Candida albican is the most common causative pathogen for candidal granuloma. We report herein the original case of a 69-year-old Chinese woman presented with a 3-year of painful cutaneous lesion on the back of left hand. Physical examination revealed a 4 × 5 cm large infiltrative reddish plaque with unclear boundaries. The yellow-white crusts were observed on the uneven surface of plaque. Histopathological examination of biopsy tissue revealed that yeast cells and the horizontal section of hyphae in the dermis by hematoxylin eosin staining and periodic acid-Schiff staining. Finally, the pathogen was identified as Candida parapsilosis by mycological examination and molecular identification. The patient was treated with itraconazole oral 200 mg twice daily combined with topical terbinafine hydrochloride cream for 2 months. The lesions were fully resolved and no recurrence was observed. Since the cutaneous infection caused by C. parasilosis were rarely reported, we also reviewed all 11 cases of cutaneous infection caused by C. parapsilosis in the PubMed. Our study highlighted that chronic unilateral infiltrated plaques or ulcers should be aware of the occurrence of fungal granuloma including candidal granuloma especially in immunocompromised patients.
ISSN:0301-486X
1573-0832
DOI:10.1007/s11046-023-00812-3