Development of guar gum reinforced calcium magnesium phosphate‐based bone biocement

This study aims at developing a calcium magnesium phosphate‐based bone biocement that combines a natural polymer and regenerative properties of bone bonding materials. The formulation of this biocement consists of oxidized guar gum, polydopamine, and calcium magnesium phosphate. The oxidized guar gu...

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Bibliographic Details
Published in:Journal of biomedical materials research. Part B, Applied biomaterials Applied biomaterials, 2024-03, Vol.112 (3), p.e35384-n/a
Main Authors: Goenka, Vidul, V. K., Anupama Devi, Manikandan, Ceera, Jaiswal, Amit Kumar
Format: Article
Language:English
Subjects:
bone biocement
Calcium
calcium magnesium phosphate
Calcium phosphates
Galactans - chemistry
Guar gum
Gums
Magnesium
Magnesium phosphate
Mannans - chemistry
Mechanical properties
Natural polymers
oxidized guar gum
Phosphates
Plant Gums
polydopamine binder solution
Polymers
Porosity
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Summary:This study aims at developing a calcium magnesium phosphate‐based bone biocement that combines a natural polymer and regenerative properties of bone bonding materials. The formulation of this biocement consists of oxidized guar gum, polydopamine, and calcium magnesium phosphate. The oxidized guar gum is easily soluble in water and has a slightly basic pH, unlike unmodified guar gum, thus allowing a homogenous paste to form in the alkaline environment of calcium magnesium phosphate. Three different oxidized degrees of guar gum were made, and the impact on the biocement properties was studied. The modified guar gum‐reinforced biocement (OGG C2) displayed higher mechanical strength and lower degradation rates than OGG B1 and OGG A0. Furthermore, samples with polydopamine exhibited better results, thus, improving the already reinforced biocement. Morphological studies of the biocement displayed a highly porous structure with porosity varying among biocement containing different oxidized guar gum and polydopamine levels.
ISSN:1552-4973
1552-4981
1552-4981
DOI:10.1002/jbm.b.35384