Cortical-sparing chronic traumatic encephalopathy (CSCTE): a distinct subtype of CTE

Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease caused by repetitive head impacts (RHI) and pathologically defined as neuronal phosphorylated tau aggregates around small blood vessels and concentrated at sulcal depths. Cross-sectional studies suggest that tau inclusions follow...

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Bibliographic Details
Published in:Acta neuropathologica 2024-06, Vol.147 (1), p.45, Article 45
Main Authors: Alexander, Abigail, Alvarez, Victor E., Huber, Bertrand R., Alosco, Michael L., Mez, Jesse, Tripodis, Yorghos, Nicks, Raymond, Katz, Douglas I., Dwyer, Brigid, Daneshvar, Daniel H., Martin, Brett, Palmisano, Joseph, Goldstein, Lee E., Crary, John F., Nowinski, Christopher, Cantu, Robert C., Kowall, Neil W., Stern, Robert A., Delalle, Ivana, McKee, Ann C., Stein, Thor D.
Format: Article
Language:English
Subjects:
Age
Alzheimer Disease
Apolipoproteins
Basal ganglia
Blood vessels
Brain
Brain stem
Central nervous system diseases
Chronic Traumatic Encephalopathy
Cognitive ability
Comorbidity
Cross-Sectional Studies
Dementia
Dementia disorders
Humans
Medicine
Medicine & Public Health
Movement disorders
Neocortex
Neurodegeneration
Neurodegenerative Diseases
Neurosciences
Original Paper
Pathology
Tau protein
Temporal lobe
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Summary:Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease caused by repetitive head impacts (RHI) and pathologically defined as neuronal phosphorylated tau aggregates around small blood vessels and concentrated at sulcal depths. Cross-sectional studies suggest that tau inclusions follow a stereotyped pattern that begins in the neocortex in low stage disease, followed by involvement of the medial temporal lobe and subcortical regions with significant neocortical burden in high stage CTE. Here, we define a subset of brain donors with high stage CTE and with a low overall cortical burden of tau inclusions (mean semiquantitative value ≤1) and classify them as cortical-sparing CTE (CSCTE). Of 620 brain donors with pathologically diagnosed CTE, 66 (11%) met criteria for CSCTE. Compared to typical high stage CTE, those with CSCTE had a similar age at death and years of contact sports participation and were less likely to carry apolipoprotein ε4 ( p  
ISSN:0001-6322
1432-0533
1432-0533
DOI:10.1007/s00401-024-02690-5