Nanoparticles as carriers of photosensitizers to improve photodynamic therapy in cancer

Photodynamic therapy (PDT) has emerged as a promising non invasive therapeutic approach for cancer treatment, offering unique advantages over conventional treatments. The combination of light activation and photosensitizing agents allows for targeted and localized destruction of cancer cells, reduci...

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Bibliographic Details
Published in:Pharmaceutical development and technology 2024-03, Vol.29 (3), p.221-235
Main Authors: Truong, Duy Hieu, Tran, Phuong Thi Thu, Tran, Tuan Hiep
Format: Article
Language:English
Subjects:
Drug Delivery Systems
Humans
Nanoparticles
Neoplasms - drug therapy
Photochemotherapy
Photosensitizing Agents
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Summary:Photodynamic therapy (PDT) has emerged as a promising non invasive therapeutic approach for cancer treatment, offering unique advantages over conventional treatments. The combination of light activation and photosensitizing agents allows for targeted and localized destruction of cancer cells, reducing damage to surrounding healthy tissues. In recent years, the integration of nanoparticles with PDT has garnered significant attention due to their potential to enhance therapeutic outcomes. This review article aims to provide a comprehensive overview of the current state-of-the-art in utilizing nanoparticles for photodynamic therapy in cancer treatment. We summarized various nanoparticle-based approaches, their properties, and their implications in optimizing PDT efficacy, and discussed challenges and prospects in the field.
ISSN:1083-7450
1097-9867
DOI:10.1080/10837450.2024.2322570