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NOS2 Polymorphism in Aspect of Left and Right-Sided Colorectal Cancer
: The NOS2 gene polymorphism rs2297518 is associated with an increased level of NO, which could contribute to colorectal cancer (CRC) development. We hypothesized that the potential influence of the NOS2 gene polymorphism on cancer development may vary between right-sided and left-sided colon cancer...
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| Published in: | Journal of clinical medicine 2024-02, Vol.13 (4), p.937 |
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| creator | Klusek, Justyna Lewitowicz, Piotr Oblap, Ruslan Orlewska, Ewa Witczak, Bartosz Marzec, Michał Tomasz Kozłowska-Geller, Monika Nawacki, Łukasz Wawszczak-Kasza, Monika Kocańda, Kamila Jóźwik, Artur Głuszek, Stanisław |
| description | : The NOS2 gene polymorphism rs2297518 is associated with an increased level of NO, which could contribute to colorectal cancer (CRC) development. We hypothesized that the potential influence of the NOS2 gene polymorphism on cancer development may vary between right-sided and left-sided colon cancers, and rectal cancers. The aim of this study was to determine the rs2297518 polymorphism influence on colorectal cancer development with regard to tumor localization.
: This case-control study included 199 patients with CRC and 120 controls. The qPCR endpoint genotyping was conducted using the TaqMan
genotyping assay.
This study revealed significant differences in tumor characteristic and in the minor alelle A frequency in the NOS2 genotype between colorectal cancers with different localizations. The mucinous adenocarcinoma was diagnosed significantly more often in right-sided cancers than in left-sided (30.6% vs. 10.9%,
= 0.009) and rectal cancers (30.6% vs. 7.1%,
= 0.0003). The minor allele A of the NOS2 genotype was observed more frequently in right-sided cancers than in left-sided cancers (44.9% vs. 23.1%,
= 0.0137) and more frequently in rectal cancers than in left-sided cancers (40.0% vs. 23.1%,
= 0.0285).
In conclusion, the results support the hypothesis that the SNP rs2297518 of the NOS2 gene influences colorectal cancer development with regard to tumor localization. |
| doi_str_mv | 10.3390/jcm13040937 |
| format | article |
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: This case-control study included 199 patients with CRC and 120 controls. The qPCR endpoint genotyping was conducted using the TaqMan
genotyping assay.
This study revealed significant differences in tumor characteristic and in the minor alelle A frequency in the NOS2 genotype between colorectal cancers with different localizations. The mucinous adenocarcinoma was diagnosed significantly more often in right-sided cancers than in left-sided (30.6% vs. 10.9%,
= 0.009) and rectal cancers (30.6% vs. 7.1%,
= 0.0003). The minor allele A of the NOS2 genotype was observed more frequently in right-sided cancers than in left-sided cancers (44.9% vs. 23.1%,
= 0.0137) and more frequently in rectal cancers than in left-sided cancers (40.0% vs. 23.1%,
= 0.0285).
In conclusion, the results support the hypothesis that the SNP rs2297518 of the NOS2 gene influences colorectal cancer development with regard to tumor localization.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm13040937</identifier><identifier>PMID: 38398251</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Analysis ; Colonoscopy ; Colorectal cancer ; Diagnosis ; DNA damage ; Genes ; Genetic aspects ; Genetic polymorphisms ; Genetic testing ; Hypotheses ; Inflammation ; Medical prognosis ; Morphology ; Mutation ; Nitric oxide ; Oxidative stress ; Pathogenesis ; Polymorphism ; Rectum ; Tumors</subject><ispartof>Journal of clinical medicine, 2024-02, Vol.13 (4), p.937</ispartof><rights>COPYRIGHT 2024 MDPI AG</rights><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-56a74514d739f1733404cd45f6acdce7c521135b1bb8a02dbf764f3f6d1117323</citedby><cites>FETCH-LOGICAL-c421t-56a74514d739f1733404cd45f6acdce7c521135b1bb8a02dbf764f3f6d1117323</cites><orcidid>0000-0001-9698-6019 ; 0000-0001-7752-0459 ; 0000-0002-5443-7975 ; 0000-0001-9653-9841 ; 0000-0001-5546-9891 ; 0000-0002-1098-8919 ; 0000-0001-5731-4316</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2930962925/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2930962925?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,25753,27924,27925,37012,37013,44590,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38398251$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Klusek, Justyna</creatorcontrib><creatorcontrib>Lewitowicz, Piotr</creatorcontrib><creatorcontrib>Oblap, Ruslan</creatorcontrib><creatorcontrib>Orlewska, Ewa</creatorcontrib><creatorcontrib>Witczak, Bartosz</creatorcontrib><creatorcontrib>Marzec, Michał Tomasz</creatorcontrib><creatorcontrib>Kozłowska-Geller, Monika</creatorcontrib><creatorcontrib>Nawacki, Łukasz</creatorcontrib><creatorcontrib>Wawszczak-Kasza, Monika</creatorcontrib><creatorcontrib>Kocańda, Kamila</creatorcontrib><creatorcontrib>Jóźwik, Artur</creatorcontrib><creatorcontrib>Głuszek, Stanisław</creatorcontrib><title>NOS2 Polymorphism in Aspect of Left and Right-Sided Colorectal Cancer</title><title>Journal of clinical medicine</title><addtitle>J Clin Med</addtitle><description>: The NOS2 gene polymorphism rs2297518 is associated with an increased level of NO, which could contribute to colorectal cancer (CRC) development. We hypothesized that the potential influence of the NOS2 gene polymorphism on cancer development may vary between right-sided and left-sided colon cancers, and rectal cancers. The aim of this study was to determine the rs2297518 polymorphism influence on colorectal cancer development with regard to tumor localization.
: This case-control study included 199 patients with CRC and 120 controls. The qPCR endpoint genotyping was conducted using the TaqMan
genotyping assay.
This study revealed significant differences in tumor characteristic and in the minor alelle A frequency in the NOS2 genotype between colorectal cancers with different localizations. The mucinous adenocarcinoma was diagnosed significantly more often in right-sided cancers than in left-sided (30.6% vs. 10.9%,
= 0.009) and rectal cancers (30.6% vs. 7.1%,
= 0.0003). The minor allele A of the NOS2 genotype was observed more frequently in right-sided cancers than in left-sided cancers (44.9% vs. 23.1%,
= 0.0137) and more frequently in rectal cancers than in left-sided cancers (40.0% vs. 23.1%,
= 0.0285).
In conclusion, the results support the hypothesis that the SNP rs2297518 of the NOS2 gene influences colorectal cancer development with regard to tumor localization.</description><subject>Analysis</subject><subject>Colonoscopy</subject><subject>Colorectal cancer</subject><subject>Diagnosis</subject><subject>DNA damage</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genetic polymorphisms</subject><subject>Genetic testing</subject><subject>Hypotheses</subject><subject>Inflammation</subject><subject>Medical prognosis</subject><subject>Morphology</subject><subject>Mutation</subject><subject>Nitric oxide</subject><subject>Oxidative stress</subject><subject>Pathogenesis</subject><subject>Polymorphism</subject><subject>Rectum</subject><subject>Tumors</subject><issn>2077-0383</issn><issn>2077-0383</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNptkctLw0AQxhdRbFFP3mXBiyCp-0o2OZbiC4oVH-ew2Ue7JcnG3eTgf--W-qjizGGG4TczH3wAnGI0obRAV2vZYIoYKijfA2OCOE8Qzen-Tj8CJyGsUYw8ZwTzQzCK0yInKR6D64fFM4GPrn5vnO9WNjTQtnAaOi176Ayca9ND0Sr4ZJerPnm2Sis4c7XzERA1nIlWan8MDoyogz75rEfg9eb6ZXaXzBe397PpPJHxcZ-kmeAsxUxxWhjMKWWIScVSkwmppOYyJRjTtMJVlQtEVGV4xgw1mcI44oQegYvt3c67t0GHvmxskLquRavdEEpSUMLo5kVEz_-gazf4NqrbUKjISEHSH2opal3a1rjeC7k5Wk55HuVhgvJITf6hYirdWOlabWyc_1q43C5I70Lw2pSdt43w7yVG5ca3cse3SJ99Sh2qRqtv9ssl-gFcK42s</recordid><startdate>20240201</startdate><enddate>20240201</enddate><creator>Klusek, Justyna</creator><creator>Lewitowicz, Piotr</creator><creator>Oblap, Ruslan</creator><creator>Orlewska, Ewa</creator><creator>Witczak, Bartosz</creator><creator>Marzec, Michał Tomasz</creator><creator>Kozłowska-Geller, Monika</creator><creator>Nawacki, Łukasz</creator><creator>Wawszczak-Kasza, Monika</creator><creator>Kocańda, Kamila</creator><creator>Jóźwik, Artur</creator><creator>Głuszek, Stanisław</creator><general>MDPI AG</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9698-6019</orcidid><orcidid>https://orcid.org/0000-0001-7752-0459</orcidid><orcidid>https://orcid.org/0000-0002-5443-7975</orcidid><orcidid>https://orcid.org/0000-0001-9653-9841</orcidid><orcidid>https://orcid.org/0000-0001-5546-9891</orcidid><orcidid>https://orcid.org/0000-0002-1098-8919</orcidid><orcidid>https://orcid.org/0000-0001-5731-4316</orcidid></search><sort><creationdate>20240201</creationdate><title>NOS2 Polymorphism in Aspect of Left and Right-Sided Colorectal Cancer</title><author>Klusek, Justyna ; 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We hypothesized that the potential influence of the NOS2 gene polymorphism on cancer development may vary between right-sided and left-sided colon cancers, and rectal cancers. The aim of this study was to determine the rs2297518 polymorphism influence on colorectal cancer development with regard to tumor localization.
: This case-control study included 199 patients with CRC and 120 controls. The qPCR endpoint genotyping was conducted using the TaqMan
genotyping assay.
This study revealed significant differences in tumor characteristic and in the minor alelle A frequency in the NOS2 genotype between colorectal cancers with different localizations. The mucinous adenocarcinoma was diagnosed significantly more often in right-sided cancers than in left-sided (30.6% vs. 10.9%,
= 0.009) and rectal cancers (30.6% vs. 7.1%,
= 0.0003). The minor allele A of the NOS2 genotype was observed more frequently in right-sided cancers than in left-sided cancers (44.9% vs. 23.1%,
= 0.0137) and more frequently in rectal cancers than in left-sided cancers (40.0% vs. 23.1%,
= 0.0285).
In conclusion, the results support the hypothesis that the SNP rs2297518 of the NOS2 gene influences colorectal cancer development with regard to tumor localization.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>38398251</pmid><doi>10.3390/jcm13040937</doi><orcidid>https://orcid.org/0000-0001-9698-6019</orcidid><orcidid>https://orcid.org/0000-0001-7752-0459</orcidid><orcidid>https://orcid.org/0000-0002-5443-7975</orcidid><orcidid>https://orcid.org/0000-0001-9653-9841</orcidid><orcidid>https://orcid.org/0000-0001-5546-9891</orcidid><orcidid>https://orcid.org/0000-0002-1098-8919</orcidid><orcidid>https://orcid.org/0000-0001-5731-4316</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Analysis Colonoscopy Colorectal cancer Diagnosis DNA damage Genes Genetic aspects Genetic polymorphisms Genetic testing Hypotheses Inflammation Medical prognosis Morphology Mutation Nitric oxide Oxidative stress Pathogenesis Polymorphism Rectum Tumors |
| title | NOS2 Polymorphism in Aspect of Left and Right-Sided Colorectal Cancer |
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