Polysensitization in the Spanish Contact Dermatitis Registry (REIDAC): A 2019-2022 prospective study with cluster and network analysis

• Published in: Journal of the European Academy of Dermatology and Venereology 2024-02
• Main Authors: Pesqué, David, Borrego, Leopoldo, Zaragoza-Ninet, Violeta, Sanz-Sánchez, Tatiana, Miquel-Miquel, Francisco Javier, González-Pérez, Ricardo, Silvestre, Juan Francisco, Córdoba-Guijarro, Susana, Carrascosa, José Manuel, Gatica-Ortega, María Elena, Ruiz-González, Inmaculada, Mercader-García, Pedro, Tous-Romero, Fátima, Ortiz de Frutos, Francisco Javier, Serra-Baldrich, Esther, Pastor-Nieto, María Antonia, Rodríguez-Serna, Mercedes, Sánchez-Pérez, Javier, Sánchez-Gilo, Araceli, Melé-Ninot, Gemma, Sánchez-Pedreño Guillén, Paloma, Pujol, Ramon Maria, Giménez-Arnau, Ana María
• Format: Article
• Language: English
• ISSN: 0926-9959; 1468-3083
• DOI: 10.1111/jdv.19934

There is still limited clinical-practice data on specific clinical and patch test features, as well as on allergen clusters in polysensitization (PS). To determine the frequency, relevance, symptoms duration and risk factors in polysensitized patients and to assess possible allergen aggregation. Prospective multicentric study (January 2019-December 2022) conducted in setting of the Spanish Contact Dermatitis Register (REIDAC). Clinical and patch test data of polysensitized and oligosensitized patients were compared, and risk factors of PS were investigated with logistic multivariate regression. Unsupervised hierarchical clustering and network analysis were used to study allergen aggregation in PS. A total of 10,176 patients were analysed. PS was found in 844 (8.3%). Current relevance was significantly higher in polysensitized patients (p