Length-Dependent Uptake of DNA-Wrapped Single-Walled Carbon Nanotubes

A length threshold for cell uptake of DNA‐wrapped single‐walled carbon nanotubes (SWNTs) by human lung fibroblasts (IMR90) is identified. Competitive uptake experiments with well‐defined and characterized length fractions show that SWNTs above the length threshold are excluded from the cell, whereas...

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Bibliographic Details
Published in:Advanced materials (Weinheim) 2007-04, Vol.19 (7), p.939-945
Main Authors: Becker, M. L., Fagan, J. A., Gallant, N. D., Bauer, B. J., Bajpai, V., Hobbie, E. K., Lacerda, S. H., Migler, K. B., Jakupciak, J. P.
Format: Article
Language:English
Subjects:
Biocompatibility
Carbon nanotubes
Carbon nanotubes, functionalized
Carbon nanotubes, single‐walled
Cells
DNA wrapping
functionalized
in vitro
Separation
single-walled
Toxicity
Toxicity, in vitro
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Summary:A length threshold for cell uptake of DNA‐wrapped single‐walled carbon nanotubes (SWNTs) by human lung fibroblasts (IMR90) is identified. Competitive uptake experiments with well‐defined and characterized length fractions show that SWNTs above the length threshold are excluded from the cell, whereas SWNTs labeled with Cy3‐derivatized DNA below the threshold are able to access the cell interior, as shown in the fluorescence image and on the cover.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.200602667