Risk Factors Associated with Intensive Care Admission in Children with Severe Acute Respiratory Syndrome Coronavirus 2-Related Multisystem Inflammatory Syndrome (MIS-C) in Latin America: A Multicenter Observational Study of the REKAMLATINA Network

• Published in: Journal of intensive care medicine 2024-08, Vol.39 (8), p.785-793
• Main Authors: Fernández-Sarmiento, Jaime, Acevedo, Lorena, Niño-Serna, Laura Fernanda, Boza, Raquel, García-Silva, Jimena, Yock-Corrales, Adriana, Yamazaki-Nakashimada, Marco A, Faugier-Fuentes, Enrique, del Águila, Olguita, Camacho-Moreno, German, Estripeaut, Dora, Gutiérrez, Iván F, Luciani, Kathia, Espada, Graciela, Álvarez-Olmos, Martha I, Pérez-Camacho, Paola, Duarte-Passos, Saulo, Cervi, Maria C, Cantillano, Edwin M, Llamas-Guillén, Beatriz A, Saltigeral-Simental, Patricia, Criales, Javier, Chacon-Cruz, Enrique, García-Domínguez, Miguel, Aguilar, Karla L Borjas, Jarovsky, Daniel, Ivankovich-Escoto, Gabriela, Tremoulet, Adriana H, Ulloa-Gutierrez, Rolando
• Format: Article
• Language: English
• Subjects: Adolescent; Child; Child, Preschool; COVID-19 - complications; COVID-19 - epidemiology; COVID-19 - mortality; COVID-19 - therapy; Female; Hospitalization - statistics & numerical data; Humans; Infant; Intensive Care Units, Pediatric - statistics & numerical data; Latin America - epidemiology; Male; Risk Factors; SARS-CoV-2; Severity of Illness Index; Systemic Inflammatory Response Syndrome - epidemiology; Systemic Inflammatory Response Syndrome - therapy
• ISSN: 0885-0666; 1525-1489; 1525-1489
• DOI: 10.1177/08850666241233189

Background: Multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease 2019 varies widely in its presentation and severity, with low mortality in high-income countries. In this study in 16 Latin American countries, we sought to characterize patients with MIS-C in the pediatric intensive care unit (PICU) compared with those hospitalized on the general wards and analyze the factors associated with severity, outcomes, and treatment received. Study Design: An observational ambispective cohort study was conducted including children 1 month to 18 years old in 84 hospitals from the REKAMLATINA network from January 2020 to June 2022. Results: A total of 1239 children with MIS-C were included. The median age was 6.5 years (IQR 2.5-10.1). Eighty-four percent (1043/1239) were previously healthy. Forty-eight percent (590/1239) were admitted to the PICU. These patients had more myocardial dysfunction (20% vs 4%; P