Successful treatment of sino-pulmonary infection & skull base osteomyelitis caused by New Delhi metallo-β-lactamase-producing Pseudomonas aeruginosa in a renal transplant recipient by using an investigational antibiotic cefepime/zidebactam (WCK 5222)

A case of sino-pulmonary infection with skull base osteomyelitis due to XDR-Pseudomonas aeruginosa in renal transplant recipient was successfully treated with investigational antibiotic, cefepime/zidebactam (WCK 5222). This case highlights challenges in managing XDR-pseudomonal infection where sourc...

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Bibliographic Details
Published in:European journal of clinical microbiology & infectious diseases 2024-02
Main Authors: Soman, Rajeev, Sirsat, Rasika, Sunavala, Ayesha, Punatar, Neha, Mehta, Jugal, Rodrigues, Camilla, Veeraraghavan, Balaji
Format: Article
Language:English
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Summary:A case of sino-pulmonary infection with skull base osteomyelitis due to XDR-Pseudomonas aeruginosa in renal transplant recipient was successfully treated with investigational antibiotic, cefepime/zidebactam (WCK 5222). This case highlights challenges in managing XDR-pseudomonal infection where source control was infeasible, antibiotic options were extremely limited and individualized dose adjustments were needed.
ISSN:0934-9723
1435-4373
DOI:10.1007/s10096-024-04791-1