Uric acid levels and heart failure: A mendelian randomization study

Uric acid, the end-product of purine metabolism within the human body, has been the subject of studies exploring its potential association with cardiovascular and cerebrovascular diseases. However, the precise relationship between uric acid levels and heart failure remains elusive. In this particula...

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Published in:Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2024-04, Vol.34 (4), p.1008-1013
Main Authors: Zheng, Jiaqi, Cen, Kaiwen, Zhang, Jiajun, Zhang, Huan, Zhao, Mingguang, Hou, Xiaowen
Format: Article
Language:English
Subjects:
Causal effects
Genome-Wide Association Study
Heart failure
Heart Failure - diagnosis
Heart Failure - epidemiology
Heart Failure - genetics
Humans
Mendelian randomization
Mendelian Randomization Analysis
Software
Uric Acid
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Summary:Uric acid, the end-product of purine metabolism within the human body, has been the subject of studies exploring its potential association with cardiovascular and cerebrovascular diseases. However, the precise relationship between uric acid levels and heart failure remains elusive. In this particular study, aggregated data from genome-wide association studies on uric acid and heart failure were utilized to perform a two-sample Mendelian randomization (MR) analysis utilizing R software. The aim was to uncover any causal link between these variables. The primary outcome was assessed using inverse variance weighted (IVW) methodology, while sensitivity analyses employed MR-Egger, weighted median (WME), and MR Pleiotropy RESidual Sum and Outlier (MR-PRESSO) techniques. IVW results revealed a possible causal relationship between elevated uric acid levels and an increased risk of heart failure (OR: 1.09, 95 % CI: 1.01–1.17, P 
ISSN:0939-4753
1590-3729
DOI:10.1016/j.numecd.2023.12.023