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Uric acid levels and heart failure: A mendelian randomization study
Uric acid, the end-product of purine metabolism within the human body, has been the subject of studies exploring its potential association with cardiovascular and cerebrovascular diseases. However, the precise relationship between uric acid levels and heart failure remains elusive. In this particula...
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| Published in: | Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2024-04, Vol.34 (4), p.1008-1013 |
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| container_title | Nutrition, metabolism, and cardiovascular diseases |
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| creator | Zheng, Jiaqi Cen, Kaiwen Zhang, Jiajun Zhang, Huan Zhao, Mingguang Hou, Xiaowen |
| description | Uric acid, the end-product of purine metabolism within the human body, has been the subject of studies exploring its potential association with cardiovascular and cerebrovascular diseases. However, the precise relationship between uric acid levels and heart failure remains elusive.
In this particular study, aggregated data from genome-wide association studies on uric acid and heart failure were utilized to perform a two-sample Mendelian randomization (MR) analysis utilizing R software. The aim was to uncover any causal link between these variables. The primary outcome was assessed using inverse variance weighted (IVW) methodology, while sensitivity analyses employed MR-Egger, weighted median (WME), and MR Pleiotropy RESidual Sum and Outlier (MR-PRESSO) techniques. IVW results revealed a possible causal relationship between elevated uric acid levels and an increased risk of heart failure (OR: 1.09, 95 % CI: 1.01–1.17, P |
| doi_str_mv | 10.1016/j.numecd.2023.12.023 |
| format | article |
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In this particular study, aggregated data from genome-wide association studies on uric acid and heart failure were utilized to perform a two-sample Mendelian randomization (MR) analysis utilizing R software. The aim was to uncover any causal link between these variables. The primary outcome was assessed using inverse variance weighted (IVW) methodology, while sensitivity analyses employed MR-Egger, weighted median (WME), and MR Pleiotropy RESidual Sum and Outlier (MR-PRESSO) techniques. IVW results revealed a possible causal relationship between elevated uric acid levels and an increased risk of heart failure (OR: 1.09, 95 % CI: 1.01–1.17, P < 0.05). Encouragingly, the directions provided by MR-Egger and WME aligned with IVW findings, and no anomalies were detected in the remaining sensitivity analyses.
These outcomes indicate the stability of the results of the study, thereby suggesting that heightened uric acid levels may contribute to an augmented risk of heart failure.
•It's the first MR study to evaluate the causal relationship between uric acid levels and heart failure.•MR study avoids the influence of confounding factors from the perspective of genetic variation.•The study has confirmed a causal relationship between uric acid levels and heart failure.</description><identifier>ISSN: 0939-4753</identifier><identifier>EISSN: 1590-3729</identifier><identifier>DOI: 10.1016/j.numecd.2023.12.023</identifier><identifier>PMID: 38413359</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Causal effects ; computer software ; Genome-Wide Association Study ; Heart failure ; Heart Failure - diagnosis ; Heart Failure - epidemiology ; Heart Failure - genetics ; Humans ; Mendelian randomization ; Mendelian Randomization Analysis ; metabolism ; nutrition ; pleiotropy ; risk ; Software ; Uric Acid ; variance</subject><ispartof>Nutrition, metabolism, and cardiovascular diseases, 2024-04, Vol.34 (4), p.1008-1013</ispartof><rights>2024 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University</rights><rights>Copyright © 2024 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c395t-4b06bfd885fc267bafc4bb9aab880386756a4fa19ff72191c764ad3bcecdf0a3</citedby><cites>FETCH-LOGICAL-c395t-4b06bfd885fc267bafc4bb9aab880386756a4fa19ff72191c764ad3bcecdf0a3</cites><orcidid>0000-0002-8490-9435</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38413359$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zheng, Jiaqi</creatorcontrib><creatorcontrib>Cen, Kaiwen</creatorcontrib><creatorcontrib>Zhang, Jiajun</creatorcontrib><creatorcontrib>Zhang, Huan</creatorcontrib><creatorcontrib>Zhao, Mingguang</creatorcontrib><creatorcontrib>Hou, Xiaowen</creatorcontrib><title>Uric acid levels and heart failure: A mendelian randomization study</title><title>Nutrition, metabolism, and cardiovascular diseases</title><addtitle>Nutr Metab Cardiovasc Dis</addtitle><description>Uric acid, the end-product of purine metabolism within the human body, has been the subject of studies exploring its potential association with cardiovascular and cerebrovascular diseases. However, the precise relationship between uric acid levels and heart failure remains elusive.
In this particular study, aggregated data from genome-wide association studies on uric acid and heart failure were utilized to perform a two-sample Mendelian randomization (MR) analysis utilizing R software. The aim was to uncover any causal link between these variables. The primary outcome was assessed using inverse variance weighted (IVW) methodology, while sensitivity analyses employed MR-Egger, weighted median (WME), and MR Pleiotropy RESidual Sum and Outlier (MR-PRESSO) techniques. IVW results revealed a possible causal relationship between elevated uric acid levels and an increased risk of heart failure (OR: 1.09, 95 % CI: 1.01–1.17, P < 0.05). Encouragingly, the directions provided by MR-Egger and WME aligned with IVW findings, and no anomalies were detected in the remaining sensitivity analyses.
These outcomes indicate the stability of the results of the study, thereby suggesting that heightened uric acid levels may contribute to an augmented risk of heart failure.
•It's the first MR study to evaluate the causal relationship between uric acid levels and heart failure.•MR study avoids the influence of confounding factors from the perspective of genetic variation.•The study has confirmed a causal relationship between uric acid levels and heart failure.</description><subject>Causal effects</subject><subject>computer software</subject><subject>Genome-Wide Association Study</subject><subject>Heart failure</subject><subject>Heart Failure - diagnosis</subject><subject>Heart Failure - epidemiology</subject><subject>Heart Failure - genetics</subject><subject>Humans</subject><subject>Mendelian randomization</subject><subject>Mendelian Randomization Analysis</subject><subject>metabolism</subject><subject>nutrition</subject><subject>pleiotropy</subject><subject>risk</subject><subject>Software</subject><subject>Uric Acid</subject><subject>variance</subject><issn>0939-4753</issn><issn>1590-3729</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNqFkE1LAzEQhoMotlb_gUiOXnZNNrvZjQehFL-g4KWeQzaZYMp-1GS3UH-9Ka0eFQbewzwzwzwIXVOSUkL53Trtxha0STOSsZRmaYwTNKWFIAkrM3GKpkQwkeRlwSboIoQ1IawkLD9HE1bllLFCTNHi3TuNlXYGN7CFJmDVGfwByg_YKteMHu7xHLfQGWic6rCP_b51X2pwfYfDMJrdJTqzqglwdcwZWj09rhYvyfLt-XUxXyaaiWJI8prw2pqqKqzOeFkrq_O6FkrVVUVYxcuCq9wqKqwtMyqoLnmuDKt1fNISxWbo9rB24_vPEcIgWxc0NI3qoB-DZLRgnNKy4v-imWCxREVJRPMDqn0fggcrN961yu8kJXIvWq7lQbTci5Y0kzHi2M3xwli3YH6HfsxG4OEARKewdeBl0A46DcZ50IM0vfv7wjfG0ZCz</recordid><startdate>20240401</startdate><enddate>20240401</enddate><creator>Zheng, Jiaqi</creator><creator>Cen, Kaiwen</creator><creator>Zhang, Jiajun</creator><creator>Zhang, Huan</creator><creator>Zhao, Mingguang</creator><creator>Hou, Xiaowen</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><orcidid>https://orcid.org/0000-0002-8490-9435</orcidid></search><sort><creationdate>20240401</creationdate><title>Uric acid levels and heart failure: A mendelian randomization study</title><author>Zheng, Jiaqi ; Cen, Kaiwen ; Zhang, Jiajun ; Zhang, Huan ; Zhao, Mingguang ; Hou, Xiaowen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c395t-4b06bfd885fc267bafc4bb9aab880386756a4fa19ff72191c764ad3bcecdf0a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Causal effects</topic><topic>computer software</topic><topic>Genome-Wide Association Study</topic><topic>Heart failure</topic><topic>Heart Failure - diagnosis</topic><topic>Heart Failure - epidemiology</topic><topic>Heart Failure - genetics</topic><topic>Humans</topic><topic>Mendelian randomization</topic><topic>Mendelian Randomization Analysis</topic><topic>metabolism</topic><topic>nutrition</topic><topic>pleiotropy</topic><topic>risk</topic><topic>Software</topic><topic>Uric Acid</topic><topic>variance</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zheng, Jiaqi</creatorcontrib><creatorcontrib>Cen, Kaiwen</creatorcontrib><creatorcontrib>Zhang, Jiajun</creatorcontrib><creatorcontrib>Zhang, Huan</creatorcontrib><creatorcontrib>Zhao, Mingguang</creatorcontrib><creatorcontrib>Hou, Xiaowen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Nutrition, metabolism, and cardiovascular diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zheng, Jiaqi</au><au>Cen, Kaiwen</au><au>Zhang, Jiajun</au><au>Zhang, Huan</au><au>Zhao, Mingguang</au><au>Hou, Xiaowen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Uric acid levels and heart failure: A mendelian randomization study</atitle><jtitle>Nutrition, metabolism, and cardiovascular diseases</jtitle><addtitle>Nutr Metab Cardiovasc Dis</addtitle><date>2024-04-01</date><risdate>2024</risdate><volume>34</volume><issue>4</issue><spage>1008</spage><epage>1013</epage><pages>1008-1013</pages><issn>0939-4753</issn><eissn>1590-3729</eissn><abstract>Uric acid, the end-product of purine metabolism within the human body, has been the subject of studies exploring its potential association with cardiovascular and cerebrovascular diseases. However, the precise relationship between uric acid levels and heart failure remains elusive.
In this particular study, aggregated data from genome-wide association studies on uric acid and heart failure were utilized to perform a two-sample Mendelian randomization (MR) analysis utilizing R software. The aim was to uncover any causal link between these variables. The primary outcome was assessed using inverse variance weighted (IVW) methodology, while sensitivity analyses employed MR-Egger, weighted median (WME), and MR Pleiotropy RESidual Sum and Outlier (MR-PRESSO) techniques. IVW results revealed a possible causal relationship between elevated uric acid levels and an increased risk of heart failure (OR: 1.09, 95 % CI: 1.01–1.17, P < 0.05). Encouragingly, the directions provided by MR-Egger and WME aligned with IVW findings, and no anomalies were detected in the remaining sensitivity analyses.
These outcomes indicate the stability of the results of the study, thereby suggesting that heightened uric acid levels may contribute to an augmented risk of heart failure.
•It's the first MR study to evaluate the causal relationship between uric acid levels and heart failure.•MR study avoids the influence of confounding factors from the perspective of genetic variation.•The study has confirmed a causal relationship between uric acid levels and heart failure.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>38413359</pmid><doi>10.1016/j.numecd.2023.12.023</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-8490-9435</orcidid></addata></record> |
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| subjects | Causal effects computer software Genome-Wide Association Study Heart failure Heart Failure - diagnosis Heart Failure - epidemiology Heart Failure - genetics Humans Mendelian randomization Mendelian Randomization Analysis metabolism nutrition pleiotropy risk Software Uric Acid variance |
| title | Uric acid levels and heart failure: A mendelian randomization study |
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