Metal-free synthesis of propargylamines via light-mediated persulfate activation and phase-transfer catalysis

We present a metal-free method to synthesize secondary and tertiary propargylamines from primary and secondary amines and alkynes using light-mediated persulfate activation and phase-transfer catalysis. Our method explores a tandem oxidative coupling/alkynylation reaction for the generation of diver...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2024-03, Vol.22 (12), p.2359-2364
Main Authors: Zaragoza, Cesar A D, Peagno, Gabriel S G, Minguine, Ana J A, Salles, Jr, Airton G
Format: Article
Language:English
Subjects:
Alkynes
Amines
Catalysis
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Summary:We present a metal-free method to synthesize secondary and tertiary propargylamines from primary and secondary amines and alkynes using light-mediated persulfate activation and phase-transfer catalysis. Our method explores a tandem oxidative coupling/alkynylation reaction for the generation of diverse compounds, highlighting the sustainability of the process and its wide scope.
ISSN:1477-0520
1477-0539
DOI:10.1039/d4ob00218k