Feasibility and acceptability of C-PRIME: A health promotion intervention for family caregivers of patients with colorectal cancer

• Published in: Supportive care in cancer 2024-03, Vol.32 (3), p.198-198, Article 198
• Main Authors: Gudenkauf, Lisa M., Li, Xiaoyin, Hoogland, Aasha I., Oswald, Laura B., lmanirad, Iman, Permuth, Jennifer B., Small, Brent J., Jim, Heather S. L., Rodriguez, Yvelise, Bryant, Crystal A., Zambrano, Kellie N., Walters, Kerie O., Reblin, Maija, Gonzalez, Brian D.
• Format: Article
• Language: English
• Subjects: Caregivers; Colorectal cancer; Data collection; Feasibility; Health promotion; Medicine; Medicine & Public Health; Nursing; Nursing Research; Oncology; Pain Medicine; Patient satisfaction; Quality of life; Rehabilitation Medicine; Self-efficacy; Sleep; Well being
• ISSN: 0941-4355; 1433-7339
• DOI: 10.1007/s00520-024-08395-5

Purpose This study aimed to test the feasibility and acceptability of a digital health promotion intervention for family caregivers of patients with advanced colorectal cancer and explore the intervention’s preliminary efficacy for mitigating the impact of caregiving on health and well-being. Methods We conducted a single-arm pilot feasibility trial of C-PRIME (Caregiver Protocol for Remotely Improving, Monitoring, and Extending Quality of Life), an 8-week digital health-promotion behavioral intervention involving monitoring and visualizing health-promoting behaviors (e.g., objective sleep and physical activity data) and health coaching (NCT05379933). A priori benchmarks were established for feasibility (≥ 50% recruitment and objective data collection; ≥ 75% session engagement, measure completion, and retention) and patient satisfaction (> 3 on a 1–5 scale). Preliminary efficacy was explored with pre- to post-intervention changes in quality of life (QOL), sleep quality, social engagement, and self-efficacy. Results Participants ( N  = 13) were M = 52 years old (SD = 14). Rates of recruitment (72%), session attendance (87%), assessment completion (87%), objective data collection (80%), and retention (100%) all indicated feasibility. All participants rated the intervention as acceptable (M = 4.7; SD = 0.8). Most participants showed improvement or maintenance of QOL (15% and 62%), sleep quality (23% and 62%), social engagement (23% and 69%), and general self-efficacy (23% and 62%). Conclusion The C-PRIME digital health promotion intervention demonstrated feasibility and acceptability among family caregivers of patients with advanced colorectal cancer. A fully powered randomized controlled trial is needed to test C-PRIME efficacy, mechanisms, and implementation outcomes, barriers, and facilitators in a divserse sample of family caregivers. Trial registration The Caregiver Protocol for Remotely Improving, Monitoring, and Extending Quality of Life (C-PRIME) study was registered on clinicaltrials.gov, NCT05379933, in May 2022.