NMR analysis of 15N-labeled naphthyridine carbamate dimer (NCD) to contiguous CGG/CGG units in DNA

The structure of the complex formed by naphthyridine carbamate dimer (NCD) binding to CGG repeat sequences in DNA, associated with fragile X syndrome, has been elucidated using 15N-labeled NCD and 1H–15N HSQC. In a fully saturated state, two NCD molecules consistently bind to each CGG/CGG unit, main...

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Published in:Chemical communications (Cambridge, England) England), 2024-03, Vol.60 (27), p.3645-3648
Main Authors: Yamada, Takeshi, Sakurabayashi, Shuhei, Sugiura, Noriaki, Haneoka, Hitoshi, Nakatani, Kazuhiko
Format: Article
Language:English
Subjects:
Binding
Dimers
Gene sequencing
Molecular structure
NMR
Nuclear magnetic resonance
Stoichiometry
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container_title Chemical communications (Cambridge, England)
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creator Yamada, Takeshi
Sakurabayashi, Shuhei
Sugiura, Noriaki
Haneoka, Hitoshi
Nakatani, Kazuhiko
description The structure of the complex formed by naphthyridine carbamate dimer (NCD) binding to CGG repeat sequences in DNA, associated with fragile X syndrome, has been elucidated using 15N-labeled NCD and 1H–15N HSQC. In a fully saturated state, two NCD molecules consistently bind to each CGG/CGG unit, maintaining a 1 : 2 binding stoichiometry.
doi_str_mv 10.1039/d4cc00544a
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subjects Binding
Dimers
Gene sequencing
Molecular structure
NMR
Nuclear magnetic resonance
Stoichiometry
title NMR analysis of 15N-labeled naphthyridine carbamate dimer (NCD) to contiguous CGG/CGG units in DNA
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