Comparison of the long-term effects of atropine in combination with Orthokeratology and defocus incorporated multiple segment lenses for myopia control in Chinese children and adolescents

• Published in: Eye (London) 2024-06, Vol.38 (9), p.1660-1667
• Main Authors: Tang, Tao, Lu, Yuchang, Li, Xuewei, Zhao, Heng, Wang, Kai, Li, Yan, Zhao, Mingwei
• Format: Article
• Language: English
• Subjects: 692/699/3161/3174; 692/700/1720; Adolescent; Age; Asian People; Atropine; Atropine - administration & dosage; Atropine - therapeutic use; Axial Length, Eye; Biometrics; Child; Children; China; Combined Modality Therapy; Contact Lenses; East Asian People; Elongation; Female; Hospitals; Humans; Laboratory Medicine; Long-term effects; Male; Medicine; Medicine & Public Health; Mydriatics - administration & dosage; Mydriatics - therapeutic use; Myopia; Myopia - drug therapy; Myopia - physiopathology; Myopia - therapy; Ophthalmology; Optometry; Orthokeratologic Procedures - methods; Pharmaceutical Sciences/Technology; Refraction, Ocular - physiology; Retrospective Studies; Surgery; Surgical Oncology; Teenagers; Treatment Outcome; Visual Acuity - physiology
• ISSN: 0950-222X; 1476-5454; 1476-5454
• DOI: 10.1038/s41433-024-02987-5

Purpose The aim of this study was to evaluate the efficacy of Orthokeratology (Ortho-K), defocus incorporated multiple segment (DIMS) lens, combined Ortho-K/atropine, and combined DIMS/atropine for myopia control in children. Methods A retrospective study included 167 myopic children aged 6–14 years with a spherical equivalent refraction (SER) of −0.75 to −4.00 diopter treated with Ortho-K (OK, n  = 41), combined Ortho-K/atropine (OKA, n  = 43), DIMS ( n  = 41), or combined DIMS/atropine (DIMSA, n  = 42). Axial length (AL) was measured at baseline and at 3, 6, 9 and 12 months. Axial elongation over time and between groups were analysed. Results After 12 months, the AL change was 0.20 ± 0.12 mm, 0.12 ± 0.14 mm, 0.22 ± 0.14 mm, and 0.15 ± 0.15 mm in the OK, OKA, DIMS, and DIMSA, respectively. There was no significant difference in AL change between OK and DIMS. OKA and DIMSA significantly slowed axial elongation compared to OK and DIMS monotherapy. After stratification by age, in the subgroup aged 6–10 years, there was significant difference in AL change between OKA and DIMS ( p  = 0.013), and no difference between other groups, while in the subgroup aged 10–14 years, the difference between OKA and DIMS became insignificant ( p  = 0.237), and the difference between OK and OKA, OK and DIMSA, DIMS and DIMSA became significant. Conclusions Ortho-K and DIMS lenses show similar reductions in myopia progression among children with low initial myopia. Atropine can significantly improve the efficacy of myopia control of both Ortho-K and DIMS lenses, and this add-on effect is better in older children.