Obstetric and Early Neonatal Outcomes Following Second and Third COVID-19 Vaccination in Pregnancy

Pregnant women are at higher risk for severe coronavirus disease 2019 (COVID-19). Since the release of the BNT162b2 messenger RNA vaccine (Pfizer/BioNTech), there has been accumulated data about the three vaccine doses. However, information regarding obstetric and neonatal outcomes of pregnant women...

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Published in:The Israel Medical Association journal 2024-01, Vol.26 (1), p.12-17
Main Authors: Peretz-Machluf, Ravit, Gilboa, Mayan, Bookstein-Peretz, Shiran, Segal, Omri, Regev, Noam, Meyer, Raanan, Regev-Yochay, Gili, Yinon, Yoav, Toussia-Cohen, Shlomi
Format: Article
Language:English
Subjects:
BNT162 Vaccine
COVID-19 - epidemiology
COVID-19 - prevention & control
COVID-19 Vaccines - adverse effects
Cross-Sectional Studies
Female
Humans
Infant, Newborn
Pregnancy
Retrospective Studies
Vaccination
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Summary:Pregnant women are at higher risk for severe coronavirus disease 2019 (COVID-19). Since the release of the BNT162b2 messenger RNA vaccine (Pfizer/BioNTech), there has been accumulated data about the three vaccine doses. However, information regarding obstetric and neonatal outcomes of pregnant women vaccinated with the third (booster) vaccine is limited and primarily retrospective. To evaluate the obstetric and early neonatal outcomes of pregnant women vaccinated during pregnancy with the COVID-19 booster vaccine compared to pregnant women vaccinated only by the first two doses. We conducted a cross-sectional study of pregnant women who received the BNT162b2 vaccine during pregnancy. Obstetric and neonatal outcomes were compared between pregnant women who received only the first two doses of the vaccine to those who also received the booster dose. Overall, 139 pregnant women were vaccinated during pregnancy with the first two doses of the vaccine and 84 with the third dose. The third dose group received the vaccine earlier during their pregnancy compared to the two doses group (212 vs. 315 weeks, respectively, P < 0.001). No differences in obstetric and early neonatal outcomes between the groups were found except for lower rates of urgent cesarean delivery in the third dose group (adjusted odds ratio 0.21; 95% confidence interval 0.048-0.926, P = 0.039). Compared to the first two doses of the BNT162b2 vaccine given in pregnancy, the booster vaccination is safe and not associated with an increased rate of adverse obstetric and early neonatal outcomes.
ISSN:1565-1088