Gut microbiota and cognitive performance: A bidirectional two-sample Mendelian randomization

Previous studies have suggested a potential association between gut microbiota and neurological and psychiatric disorders. However, the causal relationship between gut microbiota and cognitive performance remains uncertain. A two-sample Mendelian randomization (MR) study used SNPs linked to gut micr...

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Bibliographic Details
Published in:Journal of affective disorders 2024-05, Vol.353, p.38-47
Main Authors: Wang, Qian, Song, Yu-xiang, Wu, Xiao-dong, Luo, Yun-gen, Miao, Ran, Yu, Xiao-meng, Guo, Xu, Wu, De-zhen, Bao, Rui, Mi, Wei-dong, Cao, Jiang-bei
Format: Article
Language:English
Subjects:
Causal correlation
Cognitive performance
Gut microbiota
Large scale analysis
Mendelian randomization
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Summary:Previous studies have suggested a potential association between gut microbiota and neurological and psychiatric disorders. However, the causal relationship between gut microbiota and cognitive performance remains uncertain. A two-sample Mendelian randomization (MR) study used SNPs linked to gut microbiota (n = 18,340) and cognitive performance (n = 257,841) from recent GWAS data. Inverse-variance weighted (IVW), MR Egger, weighted median, simple mode, and weighted mode were employed. Heterogeneity was assessed via Cochran's Q test for IVW. Results were shown with funnel plots. Outliers were detected through leave-one-out method. MR-PRESSO and MR-Egger intercept tests were conducted to address horizontal pleiotropy influence. Limited to European populations, generic level, and potential confounding factors. IVW analysis revealed detrimental effects on cognitive perfmance associated with the presence of genus Blautia (P = 0.013, 0.966[0.940–0.993]), Catenibacterium (P = 0.035, 0.977[0.956–0.998]), Oxalobacter (P = 0.043, 0.979[0.960–0.999]). Roseburia (P 
ISSN:0165-0327
1573-2517
DOI:10.1016/j.jad.2024.02.083