The prognostic value of tumor budding in a thoroughly characterized stage II colon cancer population in the context of a national screening program

Tumor budding as a prognostic marker in colorectal cancer has not previously been investigated in a cohort of screened stage II colon cancer patients. We assessed the prognostic significance of tumor budding in a thoroughly characterized stage II colon cancer population comprising surgically resecte...

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Bibliographic Details
Published in:Human pathology 2024-04, Vol.146, p.15-22
Main Authors: Pihlmann Kristensen, Maria, Korsgaard, Ulrik, Timm, Signe, Hansen, Torben Frøstrup, Zlobec, Inti, Hager, Henrik, Kjær-Frifeldt, Sanne
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Colonic Neoplasms - mortality
Colonic Neoplasms - pathology
Denmark - epidemiology
Directed acyclic graph
Early Detection of Cancer - methods
Female
Humans
Male
Middle Aged
Neoplasm Recurrence, Local - pathology
Neoplasm Staging
Prognosis
Screening
Survival
Tumor budding
UICC stage II colon cancer
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Summary:Tumor budding as a prognostic marker in colorectal cancer has not previously been investigated in a cohort of screened stage II colon cancer patients. We assessed the prognostic significance of tumor budding in a thoroughly characterized stage II colon cancer population comprising surgically resected patients in the Region of Southern Denmark from 2014 to 2016. Tumors were re-staged according to the 8th edition of UICC TNM Classification, undergoing detailed histopathological evaluation and tumor budding assessment following guidelines from the International Tumor Budding Consensus Conference. Prognostic evaluation utilized Kaplan-Meier curves, log-rank tests, and Cox proportional hazard models for time to recurrence (TTR), recurrence-free survival (RFS), and overall survival (OS). Out of 497 patients, 20% were diagnosed through the national colorectal cancer screening program. High-grade tumor budding (Bd3) was found in 19% of tumors and was associated with glandular subtype, perineural invasion, mismatch repair proficient tumors, and tumor recurrence (p 
ISSN:0046-8177
1532-8392
1532-8392
DOI:10.1016/j.humpath.2024.02.010