Direct oral challenge for immediate and non‐immediate beta‐lactam allergy in children: A real‐world multicenter study

Background Allergy to beta‐lactam antibiotics (BLA) is frequently suspected in children, but a drug provocation test (DPT) rules it out in over 90% of cases. Direct oral DPT (DODPT), without skin or other previous tests, is increasingly been used to delabel non‐immediate BLA reactions. This real‐wor...

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Published in:Pediatric allergy and immunology 2024-03, Vol.35 (3), p.e14096-n/a
Main Authors: Moral, Luis, Toral, Teresa, Muñoz, Candelaria, Marco, Nuria, García‐Avilés, Belén, Murcia, Laura, Forniés, María José, González, María Cristina, Canals, Francisco, Bragado, Esther, Martínez Olmos, Javier, García‐Magán, Carlos, Moure González, José Domingo, Cortés, Nuria, Giménez, Magalí, Gómez, Catalina, Rodríguez, Ana Belén, Moreno, Ana, Lucas, José Manuel, Quevedo, Sergio, Blasco, Cristina, Aliaga, Yolanda
Format: Article
Language:English
Subjects:
Allergies
Anaphylaxis
Antibiotics
beta‐lactam allergy
Children
drug provocation test
Enterocolitis
Hypersensitivity (immediate)
Inflammatory bowel disease
Patients
Pediatrics
Primary care
safety
Side effects
Skin tests
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Summary:Background Allergy to beta‐lactam antibiotics (BLA) is frequently suspected in children, but a drug provocation test (DPT) rules it out in over 90% of cases. Direct oral DPT (DODPT), without skin or other previous tests, is increasingly been used to delabel non‐immediate BLA reactions. This real‐world study aimed to assess the safety and effectiveness of DODPT in children with immediate and non‐immediate reactions to BLAs. Methods Ambispective registry study in children (
ISSN:0905-6157
1399-3038
DOI:10.1111/pai.14096