Leukemia cancer cells and immune cells derived‐exosomes: Possible roles in leukemia progression and therapy

• Published in: Cell biochemistry and function 2024-03, Vol.42 (2), p.e3960-n/a
• Main Authors: Salman, Dyar Mudhafar, Mohammad, Talar Ahmad Merza
• Format: Article
• Language: English
• Subjects: Autoimmune diseases; Biological properties; Biomarkers; Biomarkers - metabolism; Cancer; Cell interactions; Dendritic cells; Diagnosis; Diagnostic systems; Exosomes; Exosomes - metabolism; extracellular vesicles; Humans; Immune system; Immunosuppressive agents; immunotherapy; Leukemia; Leukemia - diagnosis; Leukemia - metabolism; Leukemia - therapy; Malignancy; Medical prognosis; Metastases; Metastasis; Multiple sclerosis; Neoplasms - metabolism; pathobiology; Prospective Studies; Rheumatoid arthritis; Survival; Tumors
• ISSN: 0263-6484; 1099-0844
• DOI: 10.1002/cbf.3960

Exosomes have a significant impact on tumor survival, proliferation, metastasis, and recurrence. They also open up new therapeutic options and aid in the pathological identification and diagnosis of cancers. Exosomes have been shown in numerous studies to be essential for facilitating cell‐to‐cell communication. In B‐cell hematological malignancies, the proteins and RNAs that are encased by circulating exosomes are thought to represent prospective sources for therapeutic drugs as well as biomarkers for diagnosis and prognosis. Additionally, exosomes can offer a “snapshot” of the tumor and the metastatic environment at any given point in time. In this review study, we concluded that leukemia‐derived exosomes could be utilized as prognostic, diagnostic, and therapeutic biomarkers for individuals suffering from leukemia. Moreover, clinical studies have demonstrated that immune cells like dendritic cells create exosomes, which have the ability to activate the immune system against leukemia. Significant Statement Exosomes have been observed in the treatment and diagnosis of a number of illnesses and diseases, particularly B‐cell disorders like leukemia, multiple sclerosis, and rheumatoid arthritis, because of their distinct biological properties. Exosomes have a significant impact on tumor survival, proliferation, metastasis, and recurrence. Increasing evidence has indicated that leukemia‐derived exosomes could be utilized as prognostic, diagnostic, and therapeutic biomarkers for individuals suffering from leukemia. In this regard, the importance of exosomes in terms of initiation and progression of leukemia was underlined in this study.