Prevalence of osteoporosis among patients after stem cell transplantation: a systematic review and meta-analysis

The prevalence of osteoporosis in post stem cell transplantation (SCT) is poorly defined. We performed a systematic review and meta-analysis to determine the prevalence of osteoporosis in patients with hematologic diseases who underwent SCT. PubMed, EMBASE, and Web of Science were searched (from inc...

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Published in:Bone marrow transplantation (Basingstoke) 2024-06, Vol.59 (6), p.785-794
Main Authors: Yang, Yu-Mei, Guo, Shu-Jin, Xiao, Rong, Yu, Xi-Jie, Liu, Yu-Ping, Shuai, Ping
Format: Article
Language:English
Subjects:
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631/532/1542
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Blood diseases
Bone mineral density
Cell Biology
Hematological diseases
Hematology
Heterogeneity
Internal Medicine
Medical prognosis
Medicine
Medicine & Public Health
Meta-analysis
Osteopenia
Osteoporosis
Public Health
Stem cell transplantation
Stem Cells
Subgroups
Systematic review
Transplantation
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Summary:The prevalence of osteoporosis in post stem cell transplantation (SCT) is poorly defined. We performed a systematic review and meta-analysis to determine the prevalence of osteoporosis in patients with hematologic diseases who underwent SCT. PubMed, EMBASE, and Web of Science were searched (from inception to 30th April 2023) using Medical Subject Headlines to find studies that assessed the prevalence of osteoporosis among post SCT. Thirteen articles meeting the inclusion criteria were included in the analysis. The pooled prevalence rates of osteoporosis, osteopenia, and decreased bone mineral density (BMD) were determined to be 14.2% (95% CI 9.7–18.8), 36.0% (95% CI 23.8–48.2), and 47.8% (95% CI 36.6–58.9), respectively. Substantial heterogeneity was observed among the included studies (I² values ranged from 81% to 99%). Subgroup analyses revealed variations in prevalence based on gender, follow-up duration, age, region, sample size, and study quality. These findings suggest a high prevalence of osteoporosis in post-SCT patients. Given the negative impact of osteoporosis on prognosis and recipient survival, clinicians should prioritize preventive measures, early diagnosis, and effective treatments to minimize its impact.
ISSN:0268-3369
1476-5365
1476-5365
DOI:10.1038/s41409-024-02243-0