Planning for the future of maternal immunization: Building on lessons learned from the COVID-19 pandemic

As the worldwide COVID-19 pandemic unfolded, the clinical and public health community raced to understand SARS-CoV-2 infection and develop life-saving vaccines. Pregnant persons were disproportionately impacted, experiencing more severe illness and adverse pregnancy outcomes. And yet, when COVID-19...

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Bibliographic Details
Published in:Vaccine 2024-09, Vol.42, p.125644, Article 125644
Main Authors: Meaney-Delman, Dana, Carroll, Sarah, Polen, Kara, Jatlaoui, Tara C., Meyer, Sarah, Oliver, Sara, Gee, Julianne, Shimabukuro, Tom, Razzaghi, Hilda, Riley, Laura, Galang, Romeo R., Tong, Van, Gilboa, Suzanne, Ellington, Sascha, Cohn, Amanda
Format: Article
Language:English
Subjects:
Clinical trials
COVID-19
COVID-19 - epidemiology
COVID-19 - prevention & control
COVID-19 vaccines
COVID-19 Vaccines - administration & dosage
COVID-19 Vaccines - immunology
Effectiveness
Ethnic factors
Female
Humans
Immunization
Immunization - methods
Infectious diseases
Infertility
Maternal immunization
Pandemics
Pandemics - prevention & control
Pregnancy
Pregnancy Complications, Infectious - prevention & control
Public health
Safety
SARS-CoV-2 - immunology
Severe acute respiratory syndrome coronavirus 2
Vaccination
Vaccine
Vaccines
Viral diseases
Womens health
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Summary:As the worldwide COVID-19 pandemic unfolded, the clinical and public health community raced to understand SARS-CoV-2 infection and develop life-saving vaccines. Pregnant persons were disproportionately impacted, experiencing more severe illness and adverse pregnancy outcomes. And yet, when COVID-19 vaccines became available in late 2020, safety and efficacy data were not available to inform their use during pregnancy because pregnant persons were excluded from pre-authorization clinical trials. Concerns about vaccine safety during pregnancy and misinformation linking vaccination and infertility circulated widely, creating a lack of vaccine confidence. Many pregnant people initially chose not to get vaccinated, and while vaccination rates rose after safety and effectiveness data became available, COVID-19 vaccine acceptance was suboptimal and varied across racial and ethnic distribution of the pregnant population. The COVID-19 pandemic experience provided valuable insights that can inform current and future approaches to maternal vaccination against.
ISSN:0264-410X
1873-2518
1873-2518
DOI:10.1016/j.vaccine.2024.01.069