Protective role of citronellol on antioxidant enzymes and oxidative damage induced by gentamicin in experimental nephrotoxic rats

Background Gentamicin leads to nephrotoxicity with increasing oxidative stress. In the present research the role of citronellol on oxidative damage induced by gentamicin in nephrotoxic rats was evaluated. Methods and Results Forty-twomale Wistar rats were randomly divided into seven equal groups; he...

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Published in:Molecular biology reports 2024-12, Vol.51 (1), p.382-382, Article 382
Main Authors: Rahimi Monfared, Sobhan, Valibeik, Ali, Tavakoli Dastjerd, Niloufar, Jafaripour, Leila, Jafarian, Ashkan, Nabi Moradi, Mohammad, Ahmadvand, Hassan
Format: Article
Language:English
Subjects:
Animal Anatomy
Animal Biochemistry
Anti-inflammatory agents
Antioxidants
Biomedical and Life Sciences
Citronellol
Creatinine
Gene expression
Gentamicin
Glutathione peroxidase
Histology
Inflammation
Interleukin 6
Kidneys
Life Sciences
Morphology
Original Article
Oxidative stress
Tumor necrosis factor-TNF
Tumor necrosis factor-α
Vitamin E
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Summary:Background Gentamicin leads to nephrotoxicity with increasing oxidative stress. In the present research the role of citronellol on oxidative damage induced by gentamicin in nephrotoxic rats was evaluated. Methods and Results Forty-twomale Wistar rats were randomly divided into seven equal groups; healthy control, gentamicin, DMSO, citronellol 50, citronellol 100, citronellol 200 and vitamin E. The animals were anesthetized after 12 days of treatment. Kidney and serum samples were received for biochemical, histological changes, and gene expression assessments. The levels of serum glutathione (GSH), serum and kidney glutathione peroxidase (GPX) and the expression of GPX gene against gentamicin group were increased in citronellol treatment groups. The levels of serum and kidney malondialdehyde (MDA), urine protein, serum creatinine and the gene expression of inflammatory factors including tumor necrosis factor-alpha (TNF-α) and Interleukin 6 (IL-6) against gentamicin group were decreased in these groups. Moreover, recuperation in histological alterations was shown in three groups receiving citronellol compared to the gentamicin group. Conclusions Citronellol with its antioxidant and anti-inflammatory properties can decrease kidney damage caused by nephrotoxicity induced by gentamicin.
ISSN:0301-4851
1573-4978
DOI:10.1007/s11033-024-09212-2