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Causal Mediation of Neighborhood-Level Pediatric Hospitalization Inequities
Population-wide racial inequities in child health outcomes are well documented. Less is known about causal pathways linking inequities and social, economic, and environmental exposures. Here, we sought to estimate the total inequities in population-level hospitalization rates and determine how much...
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Published in: | Pediatrics (Evanston) 2024-04, Vol.153 (4), p.1 |
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creator | Brokamp, Cole Jones, Margaret N Duan, Qing Rasnick Manning, Erika Ray, Sarah Corley, Alexandra M S Michael, Joseph Taylor, Stuart Unaka, Ndidi Beck, Andrew F |
description | Population-wide racial inequities in child health outcomes are well documented. Less is known about causal pathways linking inequities and social, economic, and environmental exposures. Here, we sought to estimate the total inequities in population-level hospitalization rates and determine how much is mediated by place-based exposures and community characteristics.
We employed a population-wide, neighborhood-level study that included youth |
doi_str_mv | 10.1542/peds.2023-064432 |
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We employed a population-wide, neighborhood-level study that included youth <18 years hospitalized between July 1, 2016 and June 30, 2022. We defined a causal directed acyclic graph a priori to estimate the mediating pathways by which marginalized population composition causes census tract-level hospitalization rates. We used negative binomial regression models to estimate hospitalization rate inequities and how much of these inequities were mediated indirectly through place-based social, economic, and environmental exposures.
We analyzed 50 719 hospitalizations experienced by 28 390 patients. We calculated census tract-level hospitalization rates per 1000 children, which ranged from 10.9 to 143.0 (median 45.1; interquartile range 34.5 to 60.1) across included tracts. For every 10% increase in the marginalized population, the tract-level hospitalization rate increased by 6.2% (95% confidence interval: 4.5 to 8.0). After adjustment for tract-level community material deprivation, crime risk, English usage, housing tenure, family composition, hospital access, greenspace, traffic-related air pollution, and housing conditions, no inequity remained (0.2%, 95% confidence interval: -2.2 to 2.7). Results differed when considering subsets of asthma, type 1 diabetes, sickle cell anemia, and psychiatric disorders.
Our findings provide additional evidence supporting structural racism as a significant root cause of inequities in child health outcomes, including outcomes at the population level.</description><identifier>ISSN: 0031-4005</identifier><identifier>ISSN: 1098-4275</identifier><identifier>EISSN: 1098-4275</identifier><identifier>DOI: 10.1542/peds.2023-064432</identifier><identifier>PMID: 38426267</identifier><language>eng</language><publisher>United States: American Academy of Pediatrics</publisher><subject>Air pollution ; Asthma ; Census ; Childrens health ; Diabetes mellitus (insulin dependent) ; Health disparities ; Hospitalization ; Housing ; Mental disorders ; Pediatrics ; Population studies ; Population-based studies ; Regression analysis ; Sickle cell disease</subject><ispartof>Pediatrics (Evanston), 2024-04, Vol.153 (4), p.1</ispartof><rights>Copyright © 2024 by the American Academy of Pediatrics.</rights><rights>Copyright American Academy of Pediatrics Apr 2024</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c280t-7ee3858747a13a822cce082b2aa2a9c8603cafc14a9d835eca4a74e23f25e5a43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38426267$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brokamp, Cole</creatorcontrib><creatorcontrib>Jones, Margaret N</creatorcontrib><creatorcontrib>Duan, Qing</creatorcontrib><creatorcontrib>Rasnick Manning, Erika</creatorcontrib><creatorcontrib>Ray, Sarah</creatorcontrib><creatorcontrib>Corley, Alexandra M S</creatorcontrib><creatorcontrib>Michael, Joseph</creatorcontrib><creatorcontrib>Taylor, Stuart</creatorcontrib><creatorcontrib>Unaka, Ndidi</creatorcontrib><creatorcontrib>Beck, Andrew F</creatorcontrib><creatorcontrib>RISEUP RESEARCH TEAM</creatorcontrib><title>Causal Mediation of Neighborhood-Level Pediatric Hospitalization Inequities</title><title>Pediatrics (Evanston)</title><addtitle>Pediatrics</addtitle><description>Population-wide racial inequities in child health outcomes are well documented. Less is known about causal pathways linking inequities and social, economic, and environmental exposures. Here, we sought to estimate the total inequities in population-level hospitalization rates and determine how much is mediated by place-based exposures and community characteristics.
We employed a population-wide, neighborhood-level study that included youth <18 years hospitalized between July 1, 2016 and June 30, 2022. We defined a causal directed acyclic graph a priori to estimate the mediating pathways by which marginalized population composition causes census tract-level hospitalization rates. We used negative binomial regression models to estimate hospitalization rate inequities and how much of these inequities were mediated indirectly through place-based social, economic, and environmental exposures.
We analyzed 50 719 hospitalizations experienced by 28 390 patients. We calculated census tract-level hospitalization rates per 1000 children, which ranged from 10.9 to 143.0 (median 45.1; interquartile range 34.5 to 60.1) across included tracts. For every 10% increase in the marginalized population, the tract-level hospitalization rate increased by 6.2% (95% confidence interval: 4.5 to 8.0). After adjustment for tract-level community material deprivation, crime risk, English usage, housing tenure, family composition, hospital access, greenspace, traffic-related air pollution, and housing conditions, no inequity remained (0.2%, 95% confidence interval: -2.2 to 2.7). Results differed when considering subsets of asthma, type 1 diabetes, sickle cell anemia, and psychiatric disorders.
Our findings provide additional evidence supporting structural racism as a significant root cause of inequities in child health outcomes, including outcomes at the population level.</description><subject>Air pollution</subject><subject>Asthma</subject><subject>Census</subject><subject>Childrens health</subject><subject>Diabetes mellitus (insulin dependent)</subject><subject>Health disparities</subject><subject>Hospitalization</subject><subject>Housing</subject><subject>Mental disorders</subject><subject>Pediatrics</subject><subject>Population studies</subject><subject>Population-based studies</subject><subject>Regression analysis</subject><subject>Sickle cell disease</subject><issn>0031-4005</issn><issn>1098-4275</issn><issn>1098-4275</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNpdkD1PwzAQhi0EgvKxM6FILCyB89mpnRFVQBHlY4DZujoXMErrEidI8OtpKTAw3fA-76vTI8ShhFNZaDxbcJVOEVDlMNRa4YYYSChtrtEUm2IAoGSuAYodsZvSKwDowuC22FFW4xCHZiBuRtQnarJbrgJ1Ic6zWGd3HJ5fprF9ibHKJ_zOTfbwnbfBZ-OYFqGjJnyu-es5v_WhC5z2xVZNTeKDn7snni4vHkfjfHJ_dT06n-QeLXS5YVa2sEYbkoosovcMFqdIhFR6OwTlqfZSU1lZVbAnTUYzqhoLLkirPXGy3l208a3n1LlZSJ6bhuYc--SwVEsBRtoVevwPfY19O19-5xQorUtpbLmkYE35NqbUcu0WbZhR--EkuJVotxLtVqLdWvSycvQz3E9nXP0Vfs2qL57aeV0</recordid><startdate>20240401</startdate><enddate>20240401</enddate><creator>Brokamp, Cole</creator><creator>Jones, Margaret N</creator><creator>Duan, Qing</creator><creator>Rasnick Manning, Erika</creator><creator>Ray, Sarah</creator><creator>Corley, Alexandra M S</creator><creator>Michael, Joseph</creator><creator>Taylor, Stuart</creator><creator>Unaka, Ndidi</creator><creator>Beck, Andrew F</creator><general>American Academy of Pediatrics</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>7X8</scope></search><sort><creationdate>20240401</creationdate><title>Causal Mediation of Neighborhood-Level Pediatric Hospitalization Inequities</title><author>Brokamp, Cole ; Jones, Margaret N ; Duan, Qing ; Rasnick Manning, Erika ; Ray, Sarah ; Corley, Alexandra M S ; Michael, Joseph ; Taylor, Stuart ; Unaka, Ndidi ; Beck, Andrew F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c280t-7ee3858747a13a822cce082b2aa2a9c8603cafc14a9d835eca4a74e23f25e5a43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Air pollution</topic><topic>Asthma</topic><topic>Census</topic><topic>Childrens health</topic><topic>Diabetes mellitus (insulin dependent)</topic><topic>Health disparities</topic><topic>Hospitalization</topic><topic>Housing</topic><topic>Mental disorders</topic><topic>Pediatrics</topic><topic>Population studies</topic><topic>Population-based studies</topic><topic>Regression analysis</topic><topic>Sickle cell disease</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brokamp, Cole</creatorcontrib><creatorcontrib>Jones, Margaret N</creatorcontrib><creatorcontrib>Duan, Qing</creatorcontrib><creatorcontrib>Rasnick Manning, Erika</creatorcontrib><creatorcontrib>Ray, Sarah</creatorcontrib><creatorcontrib>Corley, Alexandra M S</creatorcontrib><creatorcontrib>Michael, Joseph</creatorcontrib><creatorcontrib>Taylor, Stuart</creatorcontrib><creatorcontrib>Unaka, Ndidi</creatorcontrib><creatorcontrib>Beck, Andrew F</creatorcontrib><creatorcontrib>RISEUP RESEARCH TEAM</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatrics (Evanston)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brokamp, Cole</au><au>Jones, Margaret N</au><au>Duan, Qing</au><au>Rasnick Manning, Erika</au><au>Ray, Sarah</au><au>Corley, Alexandra M S</au><au>Michael, Joseph</au><au>Taylor, Stuart</au><au>Unaka, Ndidi</au><au>Beck, Andrew F</au><aucorp>RISEUP RESEARCH TEAM</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Causal Mediation of Neighborhood-Level Pediatric Hospitalization Inequities</atitle><jtitle>Pediatrics (Evanston)</jtitle><addtitle>Pediatrics</addtitle><date>2024-04-01</date><risdate>2024</risdate><volume>153</volume><issue>4</issue><spage>1</spage><pages>1-</pages><issn>0031-4005</issn><issn>1098-4275</issn><eissn>1098-4275</eissn><abstract>Population-wide racial inequities in child health outcomes are well documented. Less is known about causal pathways linking inequities and social, economic, and environmental exposures. Here, we sought to estimate the total inequities in population-level hospitalization rates and determine how much is mediated by place-based exposures and community characteristics.
We employed a population-wide, neighborhood-level study that included youth <18 years hospitalized between July 1, 2016 and June 30, 2022. We defined a causal directed acyclic graph a priori to estimate the mediating pathways by which marginalized population composition causes census tract-level hospitalization rates. We used negative binomial regression models to estimate hospitalization rate inequities and how much of these inequities were mediated indirectly through place-based social, economic, and environmental exposures.
We analyzed 50 719 hospitalizations experienced by 28 390 patients. We calculated census tract-level hospitalization rates per 1000 children, which ranged from 10.9 to 143.0 (median 45.1; interquartile range 34.5 to 60.1) across included tracts. For every 10% increase in the marginalized population, the tract-level hospitalization rate increased by 6.2% (95% confidence interval: 4.5 to 8.0). After adjustment for tract-level community material deprivation, crime risk, English usage, housing tenure, family composition, hospital access, greenspace, traffic-related air pollution, and housing conditions, no inequity remained (0.2%, 95% confidence interval: -2.2 to 2.7). Results differed when considering subsets of asthma, type 1 diabetes, sickle cell anemia, and psychiatric disorders.
Our findings provide additional evidence supporting structural racism as a significant root cause of inequities in child health outcomes, including outcomes at the population level.</abstract><cop>United States</cop><pub>American Academy of Pediatrics</pub><pmid>38426267</pmid><doi>10.1542/peds.2023-064432</doi></addata></record> |
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subjects | Air pollution Asthma Census Childrens health Diabetes mellitus (insulin dependent) Health disparities Hospitalization Housing Mental disorders Pediatrics Population studies Population-based studies Regression analysis Sickle cell disease |
title | Causal Mediation of Neighborhood-Level Pediatric Hospitalization Inequities |
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