An antibacterial membrane based on Janus bacterial cellulose with nano-sized copper oxide through polydopamine conjugation for infectious wound healing

Bacterial cellulose (BC) produced by Acetobacter xylinum has great advantages in wound dressing. However, the structural limitation under static culture, and lack of antibacterial properties restrict its application, especially for infectious wound healing. The present study reported an original wou...

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Published in:Carbohydrate polymers 2024-05, Vol.332, p.121923-121923, Article 121923
Main Authors: Han, Bing, Liu, Fan, Hu, Shuhang, Chen, Xinyu, Lin, Chenming, Lee, In-Seop, Chen, Cen
Format: Article
Language:English
Subjects:
air
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Bacterial cellulose
cellulose
Cellulose - chemistry
Cellulose - pharmacology
Copper - chemistry
Copper - pharmacology
Copper oxide
cupric oxide
Gluconacetobacter xylinus
Humans
hydrophilicity
Indoles
Infection
inflammation
Janus
Oxides - pharmacology
permeability
Polydopamine
Polymers
Wound Healing
Wound Infection
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Summary:Bacterial cellulose (BC) produced by Acetobacter xylinum has great advantages in wound dressing. However, the structural limitation under static culture, and lack of antibacterial properties restrict its application, especially for infectious wound healing. The present study reported an original wound dressing, which was composed of a Janus BC membrane with antibacterial nano-sized copper oxide (CuO) through polydopamine (PDA) conjugation to promote wound healing under infectious condition. The finished product (CuO/PDA/BC membrane) exhibited favorable air permeability, high hydrophilicity and good mechanical properties, as well as strong antibacterial effects by the sustained release of CuO and photothermal effect of CuO/PDA. Furthermore, CuO/PDA/BC membrane inhibited inflammatory response and promoted wound healing in an infectious wound model in vivo. These results suggested that our CuO/PDA/BC membrane had great potential as wound dressing for infectious wound healing. [Display omitted]
ISSN:0144-8617
1879-1344
DOI:10.1016/j.carbpol.2024.121923