Characteristics of ocular hypertension and uveitic glaucoma among patients with noninfectious uveitis

• Published in: Canadian journal of ophthalmology 2024-12, Vol.59 (6), p.430-438
• Main Authors: Felfeli, Tina, Rhee, Jess, Eshtiaghi, Arshia, Balas, Michael, Tai, Felicia, Kaplan, Alexander J., Christakis, Panos G., Mandelcorn, Efrem D., Rubin, Laurence A., Bakshi, Nupura K., Derzko-Dzulynsky, Larissa A.
• Format: Article
• Language: English
• Subjects: Adult; Aged; Female; Follow-Up Studies; Glaucoma - complications; Glaucoma - diagnosis; Glaucoma - etiology; Glaucoma - physiopathology; Humans; Intraocular Pressure - physiology; Male; Middle Aged; Ocular Hypertension - diagnosis; Ocular Hypertension - etiology; Ocular Hypertension - physiopathology; Retrospective Studies; Uveitis - complications; Uveitis - diagnosis; Uveitis - drug therapy; Uveitis - physiopathology; Visual Acuity - physiology
• ISSN: 0008-4182; 1715-3360; 1715-3360
• DOI: 10.1016/j.jcjo.2024.02.003

Ocular hypertension and uveitic glaucoma are important downstream sequela of noninfectious uveitis (NIU). Herein, we describe the clinical outcomes of NIU cases with ocular hypertension and uveitic glaucoma. Retrospective cohort study. All adults (≥18 years) with NIU under the care of uveitis subspecialty tertiary care clinics between 2010 and 2021 were included. The primary outcomes were baseline and final visual acuity. A total of 216 patients out of 914 (23.6%) cases with NIU had ocular hypertension or uveitic glaucoma over the study period. Of all patients with ocular hypertension or uveitic glaucoma, 46% were corticosteroid responders. Baseline and last median visual acuities were better for the ocular hypertension patients compared with patients with uveitic glaucoma (p < 0.001). A higher proportion of patients with uveitic glaucoma than patients with ocular hypertension required glaucoma surgery (p < 0.001). The regression analyses suggested that baseline visual acuity and anatomical classification are significant predictors of last visual acuity, whereas diagnosis of ocular hypertension versus uveitic glaucoma were significant predictors of requirement for glaucoma surgery (p < 0.001). A quarter of patients with NIU in this study developed ocular hypertension or uveitic glaucoma. Approximately half of the patients with ocular hypertension or uveitic glaucoma were deemed to be corticosteroid responders. Baseline and last visual acuity outcomes are better amongst ocular hypertension patients compared with those with uveitic glaucoma. Poor baseline visual acuity and panuveitis are predictors of worse vision at last follow-up. Additionally, diagnosis of uveitic glaucoma was a significant predictor of requirement for glaucoma surgery. L'hypertension oculaire et le glaucome uvéitique sont des séquelles importantes de l'uvéite non infectieuse (UNI). Nous décrivons ici les résultats cliniques de patients qui ont présenté une hypertension oculaire ou un glaucome uvéitique au décours d'une UNI. Étude de cohorte rétrospective. Tous les adultes (≥ 18 ans) ayant présenté une UNI qui ont été traités dans des centres de soins tertiaires spécialisés dans l'uvéite entre 2010 et 2021. Les principaux paramètres évalués étaient l'acuité visuelle (AV) initiale et l'AV finale. Sur les 914 patients qui ont présenté une UNI, 216 (23,6 %) ont également présenté une hypertension oculaire ou un glaucome uvéitique au cours de la période à l’étude. Au nombre des patients qui o