Characterization of microcrystalline cellulose prepared from long and short fibers and its application in ibuprofen tablets

• Published in: International journal of biological macromolecules 2024-04, Vol.265 (Pt 1), p.130532-130532, Article 130532
• Main Authors: Hao, Xiao, Tian, Zhongjian, Wang, Yingchao, Xie, Zhaoyong, Ji, Xingxiang
• Format: Article
• Language: English
• Subjects: Hydrochloric acid hydrolysis; Ibuprofen tablets; Microcrystalline cellulose
• ISSN: 0141-8130; 1879-0003
• DOI: 10.1016/j.ijbiomac.2024.130532

As a bio-based material, microcrystalline cellulose (MCC) has been applied in many fields including pharmaceuticals, foods, and cosmetics in recent years. However, traditional preparation methods of MCC are facing many challenges due to economic and eco-environmental issues. In this study, softwood dissolved pulp was sieved to long fiber (LF) and short fiber (SF), and subsequently to prepare LF-MCC and SF-MCC by hydrochloric acid hydrolysis at different acid dosages (3–7 wt%), reaction times (30–90 min), and temperatures (75–95 °C). The as-obtained MCC products were compared in terms of morphology, size, crystallinity, and chemical structure. The results indicated that the crystallinity and yield of LF-MCC were high, with maximum values of 78.41 % and 98.68 %, respectively. The particle size distribution of SF-MCC was more uniform in the range of 20–80 μm, with a maximum of 59.44 % at 20–80 μm occupancy proportion. Moreover, SF-MCC had a typical rod-like shape and larger surface area as well as better thermal behavior than LF-MCC. When LF-MCC and SF-MCC were used as fillers in the production of ibuprofen tablets, the tablets added with LF-MCC exhibited higher hardness, friability, dissolution rate, and shorter disintegration time. Therefore, this work is very beneficial for the preparation and application of MCC. [Display omitted] •Microcrystalline cellulose (MCC) was made from long and short fibers (LF and SF).•LF-MCC showed a higher crystallinity and yield.•SF-MCC exhibited a more uniform particle size distribution and better thermal behavior.•LF-MCC and SF-MCC were used as fillers in ibuprofen tablets.•LF-MCC tablets and SF-MCC tablets showed different performance.