Inflammatory and vaso-occlusive ulcers: Part I - Clinical presentation and diagnosis

In this CME, we review 2 specific categories of ulcers: inflammatory (where inflammation is the primary pathologic process leading to ulceration) and vaso-occlusive (where occlusion is the primary process). Inflammatory ulcers include pyoderma gangrenosum and vasculitides, whereas livedoid vasculopa...

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Bibliographic Details
Published in:Journal of the American Academy of Dermatology 2024-12, Vol.91 (6), p.1035-1048
Main Authors: Shakshouk, Hadir, Hines, Alexander, Kody, Shannon, Fett, Nicole, Alavi, Afsaneh, Ortega-Loayza, Alex G.
Format: Article
Language:English
Subjects:
anti-phospholipid syndrome
autoimmune
Calciphylaxis - diagnosis
Calciphylaxis - pathology
Diagnosis, Differential
Female
Humans
inflammatory ulcers
livedoid vasculopathy
Male
martorell hypertensive ulcer
pyoderma gangrenosum
Pyoderma Gangrenosum - diagnosis
Pyoderma Gangrenosum - pathology
Skin Diseases, Vascular - diagnosis
Skin Diseases, Vascular - pathology
Skin Ulcer - diagnosis
Skin Ulcer - etiology
Skin Ulcer - pathology
vasculitis
Vasculitis - diagnosis
Vasculitis - pathology
vasculopathies
vaso-occlusive ulcers
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Description
Summary:In this CME, we review 2 specific categories of ulcers: inflammatory (where inflammation is the primary pathologic process leading to ulceration) and vaso-occlusive (where occlusion is the primary process). Inflammatory ulcers include pyoderma gangrenosum and vasculitides, whereas livedoid vasculopathy, calciphylaxis, and Martorell ulcers are vaso-occlusive ulcers. Determining the causes of ulcers in these conditions may require laboratory evaluation, biopsy, and imaging.
ISSN:0190-9622
1097-6787
1097-6787
DOI:10.1016/j.jaad.2024.01.083