Cadmium neurotoxicity and therapeutic strategies

Cadmium (Cd) is a multitarget, carcinogenic, nonessential environmental pollutant. Due to its toxic effects at very low concentrations, lengthy biological half‐life, and low excretion rate, exposure to Cd carries a concern. Prolonged exposure to Cd causes severe injury to the nervous system of both...

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Bibliographic Details
Published in:Journal of biochemical and molecular toxicology 2024-03, Vol.38 (3), p.e23670-n/a
Main Authors: Wen, Shuangquan, Wang, Liang
Format: Article
Language:English
Subjects:
Apoptosis
Autophagy
Cadmium
Carcinogens
Central nervous system
Homeostasis
Low concentrations
Neurotoxicity
Oxidative stress
therapeutic strategies
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Summary:Cadmium (Cd) is a multitarget, carcinogenic, nonessential environmental pollutant. Due to its toxic effects at very low concentrations, lengthy biological half‐life, and low excretion rate, exposure to Cd carries a concern. Prolonged exposure to Cd causes severe injury to the nervous system of both humans and animals. Nevertheless, the precise mechanisms responsible for the neurotoxic effects of Cd have yet to be fully elucidated. The accurate chemical mechanism potentially entails the destruction of metal‐ion homeostasis, inducing oxidative stress, apoptosis, and autophagy. Here we review the evidence of the neurotoxic effects of Cd and corresponding strategies to protect against Cd‐induced central nervous system injury. The specific molecular mechanisms by which cadmium induces neurotoxicity in the central nervous system.
ISSN:1095-6670
1099-0461
DOI:10.1002/jbt.23670