A Case of Idiopathic Multicentric Castleman's Disease Diagnosed From Anemia and Renal Dysfunction on an Annual Check-Up

A 34-year-old man was referred to our hospital because of mild renal dysfunction and anemia. He had no specific preexisting medical conditions; his complaint was fatigue. Physical examination revealed several mobile, pinky head-sized (no tenderness) palpable lymph nodes on the bilateral neck. Blood...

Full description

Saved in:
Bibliographic Details
Published in:Cureus 2024, Vol.16 (2), p.e53472-e53472
Main Authors: Fukui, Sayato, Yokokura, Rikako, Oshida, Jura, Kodama, Taisuke, Kobayashi, Daiki
Format: Report
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A 34-year-old man was referred to our hospital because of mild renal dysfunction and anemia. He had no specific preexisting medical conditions; his complaint was fatigue. Physical examination revealed several mobile, pinky head-sized (no tenderness) palpable lymph nodes on the bilateral neck. Blood biochemistry tests revealed anemia, renal dysfunction, increased inflammation, and a protein-albumin discrepancy. Immunological examination revealed polyclonal elevation of immunoglobulins (no shift in κ/λ ratio). A cervical lymph node biopsy was performed, and the pathological results showed numerous clusters of mature plasma cells (plasmacytic type), leading to the definitive diagnosis of idiopathic multicentric Castleman's disease (iMCD).
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.53472