Balloon neck-plasty to create a wide-necked aneurysm in the elastase-induced rabbit model

Purpose The elastase-induced aneurysm (EIA) model in rabbits has been proposed for translational research; however, the adjustment of aneurysm neck size remains challenging. In this study, the technical feasibility and safety of balloon neck-plasty to create a wide-necked aneurysm in rabbit EIA mode...

Full description

Saved in:
Bibliographic Details
Published in:Neuroradiology 2024-05, Vol.66 (5), p.825-834
Main Authors: Won, Dong-Sung, Lee, Ki Baek, Park, Jung-Hoon, Zeng, Chu Hui, Kim, Mi Hyeon, Lee, Deok Hee
Format: Article
Language:English
Subjects:
Aneurysm
Aneurysms
Animals
Area
Balloon treatment
Balloons
Carotid arteries
Carotid artery
Carotid Artery, Common
Diameters
Disease Models, Animal
Elastase
Feasibility studies
Imaging
Interventional Neuroradiology
Intracranial Aneurysm - pathology
Male
Medicine
Medicine & Public Health
Neurology
Neuroradiology
Neurosciences
Neurosurgery
Pancreatic Elastase - adverse effects
Rabbits
Radiology
Saccule
Surgery
Technology assessment
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose The elastase-induced aneurysm (EIA) model in rabbits has been proposed for translational research; however, the adjustment of aneurysm neck size remains challenging. In this study, the technical feasibility and safety of balloon neck-plasty to create a wide-necked aneurysm in rabbit EIA model were investigated. Methods Male New Zealand White rabbits ( N  = 15) were randomly assigned to three groups: group A, EIA creation without neck-plasty; group B, neck-plasty immediately after EIA creation; group C, neck-plasty 4 weeks after EIA creation. The diameter of balloon used for neck-plasty was determined 1 mm larger than origin carotid artery diameter. All rabbits were euthanized 4 weeks after their final surgery. Aneurysm neck, height, dome-to-neck ( D / N ) ratio, and histologic parameters were compared among the groups. Results Aneurysm creation was technically successful in 14 out of 15 rabbits (93.3%), with one rabbit experiencing mortality due to an adverse anesthetic event during the surgery. Saccular and wide-necked aneurysms were successfully created in all rabbits. Aneurysm neck was significantly greater in groups B and C compared to group A (all P  
ISSN:0028-3940
1432-1920
DOI:10.1007/s00234-024-03326-x