Genomic determinants of antibody response to a typhoid vaccine in Indian recipients

Typhoid is endemic in India and has high global incidence. There were large outbreaks of typhoid in India between 1990 and 2018. Available typhoid vaccines induce variable levels of protective antibodies among recipients; thus, there is variability in response to the vaccine. Interindividual genomic...

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Bibliographic Details
Published in:Journal of genetics 2024-02, Vol.103 (1), p.12-12, Article 12
Main Authors: Roy, Vijay Laxmi, Majumder, Partha Pratim
Format: Article
Language:English
Subjects:
Animal Genetics and Genomics
Antibody Formation
Biomedical and Life Sciences
blood
Evolutionary Biology
Genomics
genotyping
homeostasis
Humans
India
Life Sciences
Microbial Genetics and Genomics
phagocytosis
Plant Genetics and Genomics
Polysaccharides
Research Article
RGS Proteins
typhoid fever
Typhoid Fever - epidemiology
Typhoid Fever - prevention & control
Typhoid-Paratyphoid Vaccines - genetics
vaccines
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Summary:Typhoid is endemic in India and has high global incidence. There were large outbreaks of typhoid in India between 1990 and 2018. Available typhoid vaccines induce variable levels of protective antibodies among recipients; thus, there is variability in response to the vaccine. Interindividual genomic differences is hypothesized to be a determinant of the variability in response. We studied the antibody response of ~1000 recipients of the Vi-polysaccharide typhoid vaccine from Kolkata, India, who showed considerable variability of antibody response, i.e., anti-Vi-polysaccharide antibody level 28 days postvaccination relative to prevaccination. For each vaccinee, whole-genome genotyping was performed using the Infinium Global Screening Array (Illumina). We identified 39 SNPs that mapped to 13 chromosomal regions to be associated with antibody response to the vaccine; these included SNPs on genes LRRC28 (15q26.3), RGS7 (1q43), PTPRD (9p23), CERKL (2q31.3), DGKB (7p21.2), and TCF4 (18q21.2). Many of these loci are known to be associated with various blood cell traits, autoimmune traits and responses to other vaccines; these genes are involved in immune related functions, including TLR response, JAK–STAT signalling, phagocytosis and immune homeostasis.
ISSN:0973-7731
0973-7731
DOI:10.1007/s12041-024-01463-z