Self-Metallized Whole Cell Vaccines Prepared by Microfluidics for Bioorthogonally Catalyzed Antitumor Immunotherapy

Tumor whole cell, carrying a complete set of tumor-associated antigens and tumor-specific antigens, has shown great potential in the construction of tumor vaccines but is hindered by the complex engineering means and limited efficacy to cause immunity. Herein, we provided a strategy for the self-min...

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Bibliographic Details
Published in:ACS nano 2024-03, Vol.18 (11), p.7923-7936
Main Authors: Zeng, Fei, Pan, Yongchun, Wu, Mengnan, Lu, Qianglan, Qin, Shurong, Gao, Yanfeng, Luan, Xiaowei, Chen, Ruiyue, He, Guanzhong, Wang, Yuzhen, He, Bangshun, Chen, Zhaowei, Song, Yujun
Format: Article
Language:English
Subjects:
Antigens, Neoplasm
Cancer Vaccines
Humans
Immunotherapy
Microfluidics
Neoplasms - therapy
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Summary:Tumor whole cell, carrying a complete set of tumor-associated antigens and tumor-specific antigens, has shown great potential in the construction of tumor vaccines but is hindered by the complex engineering means and limited efficacy to cause immunity. Herein, we provided a strategy for the self-mineralization of autologous tumor cells with palladium ions in microfluidic droplets, which endowed the engineered cells with both immune and catalytic functions, to establish a bioorthogonally catalytic tumor whole-cell vaccine. This vaccine showed strong inhibition both in the occurrence and recurrence of tumor by invoking the immediate antitumor immunity and building a long-term immunity.
ISSN:1936-0851
1936-086X
DOI:10.1021/acsnano.3c09871