Design of sonochemical assisted synthesis of Zr-MOF/g-C3N4-modified electrode for ultrasensitive detection of antipsychotic drug chlorpromazine from biological samples

The rapid fabrication is described of binary electrocatalyst based on a highly porous metal–organic framework with zirconium metal core (Zr-MOF) decorated over the graphitic carbon nitride (g-C 3 N 4 ) nanosheets via facile ultrasonication method. It is used for the robust determination of antipsych...

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Bibliographic Details
Published in:Mikrochimica acta (1966) 2024-04, Vol.191 (4), p.182-182, Article 182
Main Authors: Ashkar, M. A., Kutti Rani, S., Vasimalai, N., Kuo, Chih-Yu, Yusuf, Kareem, Govindasamy, Mani
Format: Article
Language:English
Subjects:
Analytical Chemistry
Antipsychotics
Biological properties
Carbon nitride
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Chlorpromazine
Electrocatalysts
Electrochemical analysis
Electrochemical impedance spectroscopy
Electrons
Functional groups
Metal-organic frameworks
Microengineering
Nanochemistry
Nanotechnology
Original Paper
Psychotropic drugs
Surface properties
Voltammetry
X ray photoelectron spectroscopy
Zirconium
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Summary:The rapid fabrication is described of binary electrocatalyst based on a highly porous metal–organic framework with zirconium metal core (Zr-MOF) decorated over the graphitic carbon nitride (g-C 3 N 4 ) nanosheets via facile ultrasonication method. It is used for the robust determination of antipsychotic drug chlorpromazine (CLP) from environmental samples. The electrochemical behaviour of 2D Zr-MOF@g-C 3 N 4 was characterized by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) studies. The crystalline and porous nature of the composite was characterized by XRD and SEM analysis. The functional groups and surface characteristics were investigated by FT-IR, Raman and XPS. The major electrochemical properties of the Zr-MOF@g-C 3 N 4 composite towards CLP detection were analyzed by CV, chronocoulometric (CC), chronoamperometric (CA) and differential pulse voltammetry (DPV) techniques. The composite exhibits a low detection limit (LOD) of 2.45 nM with a linear range of 0.02 to 2.99 µM and attractive sensitivity for CLP. The sensor system shows higher selectivity towards the possible interferences of CLP drug and exhibits better repeatability and stability. Finally, the fabricated sensor system shows a high recovery range varying from 96.2 to 98.9% towards the real samples. The proposed electrochemical probe might be a promising alternative to the prevailing diagnostic tools for the detection of CLP. Graphical Abstract
ISSN:0026-3672
1436-5073
DOI:10.1007/s00604-024-06253-z