Epidemiological features and prognosis for primary gastrointestinal follicular lymphoma

• Published in: British journal of haematology 2024-05, Vol.204 (5), p.1771-1779
• Main Authors: Li, Xuelei, Gao, Fenghua, Meng, Xiangrui, Zhang, Xiaoyan, Sun, Cong, Liu, Hengqi, Yu, Jingwei, Liu, Xia, Han, Xue, Li, Lanfang, Qiu, Lihua, Qian, Zhengzi, Zhou, Shiyong, Gong, Wenchen, Golchehre, Zahra, Chavoshzadeh, Zahra, Ren, Xiubao, Wang, Xianhuo, Zhang, Huilai
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Epidemiology; Female; Gastrointestinal Neoplasms - diagnosis; Gastrointestinal Neoplasms - epidemiology; Gastrointestinal Neoplasms - mortality; Gastrointestinal Neoplasms - therapy; gastrointestinal tract; Humans; Incidence; Lymphoma; Lymphoma, Follicular - diagnosis; Lymphoma, Follicular - epidemiology; Lymphoma, Follicular - mortality; Lymphoma, Follicular - therapy; Lymphoma, Large B-Cell, Diffuse - diagnosis; Lymphoma, Large B-Cell, Diffuse - epidemiology; Lymphoma, Large B-Cell, Diffuse - mortality; Lymphoma, Large B-Cell, Diffuse - therapy; Male; Medical prognosis; Middle Aged; Nomograms; population‐based analysis; Prognosis; rare diseases; Retrospective Studies; risk factors; Risk groups; SEER; SEER Program; Young Adult
• ISSN: 0007-1048; 1365-2141
• DOI: 10.1111/bjh.19393

Summary Primary gastrointestinal follicular lymphoma (PGI‐FL) is a rare extra‐nodal lymphoma. Its epidemiology and prognosis remain unclear. We performed a retrospective analysis of eligible patients with 1648 PGI‐FL and 34 892 nodal FL (N‐FL) in the Surveillance, Epidemiology and End Results (SEER) database. The age‐adjusted average annual incidence of PGI‐FL was 0.111/100000. The median overall survival (OS) for PGI‐FL and N‐FL patients was 207 and 165 months respectively. The 5‐year diffuse large B‐cell lymphoma (DLBCL) transformation rates were 2.1% and 2.6% respectively. Age, sex, grade, Ann Arbor stage, primary site and radiation were independent prognostic factors (p