OGT and OGA: Sweet guardians of the genome

The past 4 decades have witnessed tremendous efforts in deciphering the role of O-GlcNAcylation in a plethora of biological processes. Chemists and biologists have joined hand in hand in the sweet adventure to unravel this unique and universal yet uncharted post-translational modification, and the r...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of biological chemistry 2024-04, Vol.300 (4), p.107141-107141, Article 107141
Main Authors: Wu, Chen, Li, Jiaheng, Lu, Lingzi, Li, Mengyuan, Yuan, Yanqiu, Li, Jing
Format: Article
Language:English
Subjects:
DNA damage
O-GlcNAc
OGA
OGT
replication
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The past 4 decades have witnessed tremendous efforts in deciphering the role of O-GlcNAcylation in a plethora of biological processes. Chemists and biologists have joined hand in hand in the sweet adventure to unravel this unique and universal yet uncharted post-translational modification, and the recent advent of cutting-edge chemical biology and mass spectrometry tools has greatly facilitated the process. Compared with O-GlcNAc, DNA damage response (DDR) is a relatively intensively studied area that could be traced to before the elucidation of the structure of DNA. Unexpectedly, yet somewhat expectedly, O-GlcNAc has been found to regulate various DDR pathways: homologous recombination, nonhomologous end joining, base excision repair, and translesion DNA synthesis. In this review, we first cover the recent structural studies of the O-GlcNAc transferase and O-GlcNAcase, the elegant duo that “writes” and “erases” O-GlcNAc modification. Then we delineate the intricate roles of O-GlcNAc transferase and O-GlcNAcase in DDR. We envision that this is only the beginning of our full appreciation of how O-GlcNAc regulates the blueprint of life—DNA.
ISSN:0021-9258
1083-351X
DOI:10.1016/j.jbc.2024.107141