Enhancement of Permeation in Transdermal Drug Delivery System by 6mum Wavelength Area Using an MIR-FEL

Ablation of the stratum corneum (SC) by pulsed-laser irradiation is one method of enhancing transdermal drug delivery (TD). For non-invasive laser TD treatment, we have tried to enhance TD without ablation of the SC using an MIR-FEL (6-mum wavelength) (FEL : free electron laser). Lidocaine was used...

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Bibliographic Details
Published in:4th International Symposium on Therapeutic Ultrasound 2005-01, Vol.754, p.110-112
Main Authors: Uchizono, T, Ishii, K, Iwao, Y, Itou, Y, Maruo, H, Hori, M, Awazu, K
Format: Article
Language:English
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Summary:Ablation of the stratum corneum (SC) by pulsed-laser irradiation is one method of enhancing transdermal drug delivery (TD). For non-invasive laser TD treatment, we have tried to enhance TD without ablation of the SC using an MIR-FEL (6-mum wavelength) (FEL : free electron laser). Lidocaine was used as the drug in this study. The enhancement of TD was measured by HPLC. It was found that the lidocaine TD of the sample irradiated by MIR-FEL was enhanced 10 fold faster than the non-irradiated sample with a flux at 0.5 mug/cm2/h, measured by HPLC. We have demonstrated the effectiveness of TD enhancement by an MIR-FEL (6-mum wavelength) irradiation.
ISSN:0094-243X
DOI:10.1063/1.1901613