Enzyme-Mediated Degradation of Peptide-Amphiphile Nanofiber Networks

Peptide‐amphiphile nanofibers are prepared that incorporate a peptide sequence permitting enzyme‐mediated degradation (see Figure). Cleavage of the peptide sequence results in breakdown of the nanostructure and, consequently, the mechanical properties. This novel elastic nanofiber network is able to...

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Bibliographic Details
Published in:Advanced materials (Weinheim) 2005-11, Vol.17 (21), p.2612-2617
Main Authors: Jun, H.-W., Yuwono, V., Paramonov, S. E., Hartgerink, J. D.
Format: Article
Language:English
Subjects:
Biocompatible materials
Hydrogels
Proteins
Self-assembly
Tissue engineering
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Summary:Peptide‐amphiphile nanofibers are prepared that incorporate a peptide sequence permitting enzyme‐mediated degradation (see Figure). Cleavage of the peptide sequence results in breakdown of the nanostructure and, consequently, the mechanical properties. This novel elastic nanofiber network is able to encapsulate dental pulp cells, supporting their proliferation and migration, and mimics several key properties of natural extracellular matrix.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.200500855