Selective and Effective Cytotoxicity of Folic Acid-conjugated Cholesteryl Pullulan Hydrogel Nanoparticles Complexed with Doxorubicin in In Vitro and In Vivo Studies

We previously reported that cholesteryl pullulan (CHP) derivatives were effective carriers drug delivery systems in targeting cancer cells. We have now synthesized folic acid-conjugated CHP hydrogel nanoparticles (FA-CHP). FA-CHP complexed with the anticancer drug doxorubicin (DOX) show a higher cyt...

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Bibliographic Details
Published in:Journal of bioactive and compatible polymers 2006-11, Vol.21 (6), p.591-602
Main Authors: Hidaka, M, Kanematsu, T, Ushio, K, Sunamoto, J
Format: Article
Language:English
Online Access:Get full text
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Summary:We previously reported that cholesteryl pullulan (CHP) derivatives were effective carriers drug delivery systems in targeting cancer cells. We have now synthesized folic acid-conjugated CHP hydrogel nanoparticles (FA-CHP). FA-CHP complexed with the anticancer drug doxorubicin (DOX) show a higher cytotoxicity than CHP complexed with DOX in in vitro studies. The expression of a folate receptor (FR) is elevated in many cancers; in this case, confocal image analysis revealed that FA-CHP complexed with DOX exhibited greater cellular uptake than CHP complexed with DOX in human epidermal carcinoma (KB) cells over-expressing surface FR.
ISSN:0883-9115
DOI:10.1177/0883911506069871