Determination of n-octanol–water partition coefficients by hollow-fiber membrane solvent microextraction coupled with HPLC

A novel direct method has been developed for determination of n-octanol–water partition coefficients by hollow-fiber membrane solvent microextraction (HFMSME) combined with high-performance liquid chromatography (HPLC). The compound of interest is dissolved in water with sonication and a hollow fibe...

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Bibliographic Details
Published in:Analytical and bioanalytical chemistry 2006-12, Vol.386 (7-8), p.2193-2198
Main Authors: Guo, Yu Gao, Zhang, Jie, Liu, Dan Ning, Fu, Hua Feng
Format: Article
Language:English
Subjects:
1-Octanol - chemistry
Aniline Compounds - chemistry
Chromatography, High Pressure Liquid - methods
fibers
high performance liquid chromatography
microextraction
octanol
partition coefficients
Solvents
Water - chemistry
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Summary:A novel direct method has been developed for determination of n-octanol–water partition coefficients by hollow-fiber membrane solvent microextraction (HFMSME) combined with high-performance liquid chromatography (HPLC). The compound of interest is dissolved in water with sonication and a hollow fiber containing octanol inside is placed in the sample solution to perform microextraction. After microextraction the concentrations in both the aqueous and n-octanol phases are analyzed by HPLC with UV detection. The method was evaluated with ten reference compounds and shown to be suitable for determination of the partition coefficients of organic compounds accurately, cheaply, simply, and quickly. Previously unknown n-octanol–water partition coefficients have been obtained for other compounds by use of the hollow-fiber membrane solvent-microextraction technique.
ISSN:1618-2642
1618-2650
DOI:10.1007/s00216-006-0868-5