Direct NanoSIMS imaging of diffusible elements in surfaced block of cryo-processed biological samples

A sample preparation has been developed for NanoSIMS 50 analysis of biological samples, that does not require thin sectioning. The embedded sample was surfaced by a diamond knife and directly analyzed. This sample preparation technique is well adapted for the investigation of diffusible elements and...

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Bibliographic Details
Published in:Applied surface science 2006-07, Vol.252 (19), p.6706-6708
Main Authors: Hallégot, P., Audinot, J.-N., Migeon, H.-N.
Format: Article
Language:English
Subjects:
Biological sample
Condensed matter: electronic structure, electrical, magnetic, and optical properties
Condensed matter: structure, mechanical and thermal properties
Cross-disciplinary physics: materials science
rheology
Diffusible elements
Exact sciences and technology
Human hair
NanoSIMS
Physics
Sample preparation
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Summary:A sample preparation has been developed for NanoSIMS 50 analysis of biological samples, that does not require thin sectioning. The embedded sample was surfaced by a diamond knife and directly analyzed. This sample preparation technique is well adapted for the investigation of diffusible elements and an example of iodine-containing water-soluble molecule localization in human hair is shown. We compared the results with conventional thin wet sectioning.
ISSN:0169-4332
1873-5584
DOI:10.1016/j.apsusc.2006.02.258