Evaluating oxidative stress biomarkers in oncology nurses exposed to antineoplastic drugs: A cross-sectional study

Antineoplastic drugs (ADs) are widely used in cancer treatment. Nurses in chemotherapy centers are exposed to these drugs during preparation. They can affect healthy cells, leading to teratogenic and mutagenic effects, as well as oxidative stress. This study aimed to evaluate oxidative stress biomar...

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Bibliographic Details
Published in:European journal of oncology nursing : the official journal of European Oncology Nursing Society 2024-04, Vol.69, p.102536-102536, Article 102536
Main Authors: Abdollahi, Tahere, Ranjbar, Akram, Faradmal, Javad, Mohraz, Majid Habibi, Assari, Mohammad Javad
Format: Article
Language:English
Subjects:
Antineoplastic agents
Biomarkers
Nurses
Oxidative stress
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Summary:Antineoplastic drugs (ADs) are widely used in cancer treatment. Nurses in chemotherapy centers are exposed to these drugs during preparation. They can affect healthy cells, leading to teratogenic and mutagenic effects, as well as oxidative stress. This study aimed to evaluate oxidative stress biomarkers in the nurses exposed to these drugs. This study was conducted on 30 nurses exposed to ADs and 30 nurses with no exposure to these drugs as non-exposed group. Oxidative stress biomarkers were measured in the blood serum samples of both groups, including malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), total antioxidant capacity (TAC), and blood thiol groups. Considering the possibility of confounding effect of nutritional supplement consumption, the effect of this factor was adjusted in the analysis. A significant difference was observed for CAT, SOD, thiol, and TAC biomarkers between two groups (P 
ISSN:1462-3889
1532-2122
DOI:10.1016/j.ejon.2024.102536