Laparoscopic retroperitoneal lymphadenectomy for ovarian mixed germ cell tumor in a patient with situs inversus totalis; reporting the first case worldwide with literature review and in silico analysis

Situs inversus totalis (SIT) is a rare autosomal recessive inheritance at which the abdomino-thoracic organs are mirror-image transposed. Germ cell tumors originate from the primitive germ cell of the ovary and testis. A rare association between malignant ovarian mixed germ cell tumor and SIT was pr...

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Bibliographic Details
Published in:Pathology, research and practice research and practice, 2024-04, Vol.256, p.155228-155228, Article 155228
Main Authors: Hafez, Ahmed Shoukry, Asar, Mohammed Mamdouh, Farid, Sayed, Abdelsamad, Ahmed, Hamdy, Nadia M.
Format: Article
Language:English
Subjects:
Case report
in silico analysis
Lymphadenectomy
Malignant ovarian germ cell tumors (MOGCT)
Situs inversus totalis (SIT)
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Summary:Situs inversus totalis (SIT) is a rare autosomal recessive inheritance at which the abdomino-thoracic organs are mirror-image transposed. Germ cell tumors originate from the primitive germ cell of the ovary and testis. A rare association between malignant ovarian mixed germ cell tumor and SIT was presented in a 32-years-old Egyptian female, successfully treated with laparoscopic total abdominal hysterectomy, right salpingo-oophorectomy, and retroperitoneal lymphadenectomy (laparoscopic retroperitoneal lymphadenectomy) of both sides. This case is considered the first of its kind worldwide. SIT may be associated with malignant ovarian germ cell tumors. Surgical intervention could be done laparoscopically.
ISSN:0344-0338
1618-0631
DOI:10.1016/j.prp.2024.155228